Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis

Autor(es)

Alves, Joao Manoel ^[1] ; Gomes Teles, Ramon Handerson ^[2] ; Gomes Gatto, Camila do Valle ^[3] ; Munoz, Vitor Rosetto ^[4] ; Cominetti, Marcia Regina ^[2] ; Garcia de Oliveira Duarte, Ana Claudia ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Carlos UFSCar, Dept Phys Educ, BR-13565905 Sao Carlos, SP - Brazil

^[2] Fed Univ Sao Carlos UFSCar, Dept Gerontol, BR-13565905 Sao Carlos, SP - Brazil

^[3] Univ Sao Paulo, Lab Biochem & Mol Biol Exercise, BR-05508030 Sao Paulo, SP - Brazil

^[4] Univ Estadual Campinas, UNICAMP, Lab Mol Biol Exercise LaBMEx, Sch Appl Sci, BR-13484350 Limeira, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLS; v. 8, n. 12 DEC 2019.
• Citações Web of Science: 0

Resumo

Recent studies have investigated the control of adipose tissue expansion and inflammatory process by microRNAs (miRNAs). These two processes are of great interest because both are associated with obesity and metabolic syndrome. However, despite the great relevance of the role of miRNAs in obesity and adipose tissue, no qualitative and quantitative analysis on the subject has been performed. Thus, we aimed to examine global research activity and current trends with respect to the interaction between obesity, adipose tissue and miRNAs through a bibliometric analysis. This research was performed on the Scopus database for publications containing miRNA, obesity, and adipose tissue keyword combinations. In total, 898 articles were analyzed and the most frequently occurring keywords were selected and clustered into three well-defined groups. As a result, first group of keywords pointed to the research area on miRNAs expressed in obesity-associated diseases. The second group demonstrated the regulation of the adipogenesis process by miRNAs, while the third group highlighted brown adipose tissue and thermogenesis as one of the latest global research trends related to the theme. The studies selected in this paper describe the expression and performance of different miRNAs in obesity and comorbidities. Most studies have focused on identifying miRNAs and signaling pathways associated with obesity, type 2 diabetes mellitus, and cardiovascular disease. Thus, the miRNA profile for these diseases may be used as biomarkers and therapeutic targets in the prevention and treatment of obesity-associated diseases. (AU)

• Processo FAPESP: 17/19504-0 - Avaliação da atividade de complexos de rutênio encapsulados sobre metástases de tumor de mama triplo negativo
• Beneficiário: Ramon Handerson Gomes Teles
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 17/09602-4 - Estudo longitudinal dos marcadores metabólicos e fisiológicos no desenvolvimento da obesidade e síndrome metabólica em ratos alimentados com dieta hiperlipídica
• Beneficiário: Ana Cláudia Garcia de Oliveira Duarte
• Modalidade de apoio: Auxílio à Pesquisa - Regular