Insights into the Chemical Biology of Childhood Embryonal Solid Tumors by NMR-Based Metabolomics

Autor(es)

Escobar, Melissa Quintero ^{[1, 2]} ; Maschietto, Mariana ^[3] ; Krepischi, V, Ana C. ; Avramovic, Natasa ^[4] ; Tasic, Ljubica ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Dept Organ Chem, Biol Chem Grp, BR-13083970 Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, UNICAMP, Dept Med Physiopathol, Lab Blood Coagulat, Hemoctr, BR-13083878 Campinas, SP - Brazil

^[3] Boldrini Childrens Hosp, Res Ctr, BR-13083884 Campinas, SP - Brazil

^[4] Univ Belgrade, Fac Med, Inst Med Chem, Belgrade 11000 - Serbia

• Tipo de documento: Artigo de Revisão
• Fonte: BIOMOLECULES; v. 9, n. 12 DEC 2019.
• Citações Web of Science: 0

Resumo

Most childhood cancers occur as isolated cases and show very different biological behavior when compared with cancers in adults. There are some solid tumors that occur almost exclusively in children among which stand out the embryonal solid tumors. These cancers main types are neuroblastoma, nephroblastoma (Wilms tumors), retinoblastoma and hepatoblastomas and tumors of the central nervous system (CNS). Embryonal solid tumors represent a heterogeneous group of cancers supposedly derived from undifferentiated cells, with histological features that resemble tissues of origin during embryogenesis. This key observation suggests that tumorigenesis might begin during early fetal or child life due to the errors in growth or pathways differentiation. There are not many literature data on genomic, transcriptomic, epigenetic, proteomic, or metabolomic differences in these types of cancers when compared to the omics- used in adult cancer research. Still, metabolomics by nuclear magnetic resonance (NMR) in childhood embryonal solid tumors research can contribute greatly to understand better metabolic pathways alterations and biology of the embryonal solid tumors and potential to be used in clinical applications. Different types of samples, such as tissues, cells, biofluids, mostly blood plasma and serum, can be analyzed by NMR to detect and identify cancer metabolic signatures and validated biomarkers using enlarged group of samples. The literature search for biomarkers points to around 20-30 compounds that could be associated with pediatric cancer as well as metastasis. (AU)

• Processo FAPESP: 18/18624-4 - Análises metabolômicas e metabonômicas por técnicas de ressonância magnética nuclear aplicadas em estudos da trombose venosa
• Beneficiário: Melissa Quintero Escobar
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 15/06281-7 - Investigação da regulação epigenética em tumores sólidos pediátricos
• Beneficiário: Mariana Camargo Maschietto
• Linha de fomento: Bolsas no Brasil - Apoio a Jovens Pesquisadores
• Processo FAPESP: 18/06510-4 - Aplicação de Ressonância Magnética Nuclear (RMN) em metabolômica e metabonômica de doenças humanas
• Beneficiário: Ljubica Tasic
• Linha de fomento: Auxílio à Pesquisa - Regular