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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Insights into the Chemical Biology of Childhood Embryonal Solid Tumors by NMR-Based Metabolomics

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Author(s):
Escobar, Melissa Quintero [1, 2] ; Maschietto, Mariana [3] ; Krepischi, V, Ana C. ; Avramovic, Natasa [4] ; Tasic, Ljubica [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Dept Organ Chem, Biol Chem Grp, BR-13083970 Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, UNICAMP, Dept Med Physiopathol, Lab Blood Coagulat, Hemoctr, BR-13083878 Campinas, SP - Brazil
[3] Boldrini Childrens Hosp, Res Ctr, BR-13083884 Campinas, SP - Brazil
[4] Univ Belgrade, Fac Med, Inst Med Chem, Belgrade 11000 - Serbia
Total Affiliations: 4
Document type: Review article
Source: BIOMOLECULES; v. 9, n. 12 DEC 2019.
Web of Science Citations: 0
Abstract

Most childhood cancers occur as isolated cases and show very different biological behavior when compared with cancers in adults. There are some solid tumors that occur almost exclusively in children among which stand out the embryonal solid tumors. These cancers main types are neuroblastoma, nephroblastoma (Wilms tumors), retinoblastoma and hepatoblastomas and tumors of the central nervous system (CNS). Embryonal solid tumors represent a heterogeneous group of cancers supposedly derived from undifferentiated cells, with histological features that resemble tissues of origin during embryogenesis. This key observation suggests that tumorigenesis might begin during early fetal or child life due to the errors in growth or pathways differentiation. There are not many literature data on genomic, transcriptomic, epigenetic, proteomic, or metabolomic differences in these types of cancers when compared to the omics- used in adult cancer research. Still, metabolomics by nuclear magnetic resonance (NMR) in childhood embryonal solid tumors research can contribute greatly to understand better metabolic pathways alterations and biology of the embryonal solid tumors and potential to be used in clinical applications. Different types of samples, such as tissues, cells, biofluids, mostly blood plasma and serum, can be analyzed by NMR to detect and identify cancer metabolic signatures and validated biomarkers using enlarged group of samples. The literature search for biomarkers points to around 20-30 compounds that could be associated with pediatric cancer as well as metastasis. (AU)

FAPESP's process: 18/18624-4 - Metabolomic and metabonomic analyzes by nuclear magnetic resonance techniques applied in studies of venous thrombosis
Grantee:Melissa Quintero Escobar
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/06281-7 - CHARACTERIZATION OF THE EPIGENETIC REGULATION IN HUMAN SOLID PAEDIATRIC TUMOURS
Grantee:Mariana Camargo Maschietto
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 18/06510-4 - Application of Nuclear Magnetic Resonance (NMR) in metabolomics and metabonomics of human diseases
Grantee:Ljubica Tasic
Support Opportunities: Regular Research Grants