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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Impact of Immune System Activation and Vascular Impairment on Male and Female Sexual Dysfunction

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Calmasini, Fabiano B. [1, 2] ; Klee, Nicole [2] ; Webb, R. Clinton [2] ; Priviero, Fernanda [2]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, BR-13083881 Campinas, SP - Brazil
[2] Augusta Univ, Med Coll Georgia, Dept Physiol, Augusta, GA - USA
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: SEXUAL MEDICINE REVIEWS; v. 7, n. 4, p. 604-613, OCT 2019.
Citações Web of Science: 0

Introduction: Male and female sexual dysfunction (SD) is considered a multifactorial condition. Numerous studies have shown the involvement of inflammatory processes in this pathological condition. Sexual intercourse requires healthy and functioning vessels to supply the pelvic region in both males and females, generating penile erection and clitoral and vaginal lubrication, respectively. Cardiovascular diseases and associated risk factors may contribute negatively to pelvic blood flow, possibly through immune system activation. Aim: The study aimed to address the correlation between vascular inflammation driven by immune system activation and SD in males and females. Methods: A literature review was performed to identify articles addressing male and female SD and vascular inflammation. Key words included ``male and female sexual dysfunction,{''} ``vascular inflammation,{''} ``iliac and pudendal arteries dysfunction,{''} ``genitourinary tract,{''} and ``blood flow.{''} Main Outcome Measures: Management of systemic and local inflammation may be a useful alternative to improve SD and reduce the risk of cardiovascular diseases in the future. Results: Increased levels of cytokines and chemokines have been detected in humans and animals with hypertension, obesity, and diabetic conditions. Chronic activation of the innate immune system, especially by pathogen- or damage-associated molecular patterns, and metabolic-related disorders may act as triggers further contributing to an increased inflammatory condition. Due to the reduced size of vessels, SD and retinal vascular impairments have been shown to be predictive factors for cardiovascular diseases. Therefore, considering that blood flow to the genitalia is essential for sexual function, endothelial dysfunction and vascular remodeling, secondary to chronic immune system activation, may be implicated in male and female vasculogenic SD. Conclusions: Several conditions appear to play a role in SD. In the present review, we have identified a role for the immune system in generating vascular and tissue impairments contributing to erectile dysfunction and female SD. Copyright (C) 2019, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 16/20592-8 - Participação dos receptores toll-like 9 (TLR9) na disfunção prostática de camundongos obesos resistentes a insulina
Beneficiário:Fabiano Beraldi Calmasini
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado