Palladium(II) complexes bearing thiosemicarbazone and phosphines as inhibitors of DNA-Topoisomerase II enzyme: Synthesis, characterizations and biological studies

Autor(es)

Lima, Mauro Almeida ^[1] ; Costa, Vinicius A. ^[1] ; Franco, Mariane Aralijo ^[1] ; de Oliveira, Gabriela P. ^[1] ; Deflon, Victor M. ^[2] ; Rocha, Fillipe Vieira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim Sao Carlos, Ave Trabalhador Sao Carlense 400, BR-13566590 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Inorganic Chemistry Communications; v. 112, FEB 2020.
• Citações Web of Science: 1

Resumo

Four new palladium(II) complexes bearing thiosemicarbazone and phosphines as ligands were synthesized and fully characterized by IR, NMR, UV-Vis spectroscopies, elemental analysis and X-ray diffraction. The metal complexes were tested towards five cell lines, including, tumor and non-tumor cells. Cytotoxicity of the palladium(II) complexes overcame cisplatin. Compounds did not interacted with the DNA. However, palladium(II) complexes showed an inhibition of action of the Topoisomerase II enzyme at lower concentrations than did etoposide, a standard drug. (AU)

• Processo FAPESP: 16/04201-9 - Compostos de metais de transição contendo tiossemicarbazonas e fosfinas como ligantes: Investigação da citotoxicidade e mecanismo de ação
• Beneficiário: Fillipe Vieira Rocha
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/11242-1 - Quantificação relativa de enzimas DNA-Topoisomerase em linhagens celulares: estreitamento da correlação citotoxicidade-mecanismo de ação de compostos de coordenação
• Beneficiário: Fillipe Vieira Rocha
• Modalidade de apoio: Auxílio à Pesquisa - Regular