Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Altered maternal metabolism during mild gestational hyperglycemia as a predictor of adverse perinatal outcomes: A comprehensive analysis

Texto completo
Autor(es):
Mostrar menos -
Cunha Rudge, Marilza Vieira [1, 2] ; Pascon Barbosa, Angelica Mercia [2, 3] ; Sobrevia, Luis [2, 4, 5, 6] ; Gelaleti, Rafael Bottaro [2] ; Shetty Hallur, Raghavendra Lakshmana [2] ; Castro Marcondes, Joao Paulo [2] ; Favero Salvadori, Daisy Maria [7] ; Prudencio, Caroline Baldini [2] ; Magalhaes, Claudia Garcia [1] ; Costa, Roberto [1] ; Abbade, Joelcio Francisco [1] ; Corrente, Jose Eduardo [8] ; Paranhos Calderon, Iracema de Mattos [1, 2] ; Rudge, V, M. ; Calderon, I. M. P. ; Barbosa, A. P. ; Abbade, J. ; Costa, R. A. A. ; Magalhaes, C. G. ; Salvadori, D. F. ; Gelaleti, R. ; Hallur, R. L. S. ; Marcondes, J. P. ; Floriano, J. F. ; Reyes, D. R. A. ; Sobrevia, L. ; Prudencio, C. B. ; Piculo, F. ; Marini, G. ; Vesentini, G. ; Morceli, G. ; Negrato, C. A. ; Prazeres, H. D. ; Molina, S. ; Arantes, M. ; Cavassini, A. C. ; Kerche, L. ; De Luca, A. K. C. ; Correa-Silva, S. ; Bevilacqua, E. ; Moreli, J. B. ; Pietro, L. ; Daher, S. ; Fabio, S. ; Honorio-Franca, A. C. ; Queiroz, A. A. ; Hara, C. C. P. ; Boraschi, C. A. L. ; Pauletti, T. A. V. L. ; Jovanovic, L. ; Dias, A. ; Atallah, A. N. ; Ramos, M. D. ; Brasil, M. A. M. ; Rudge, C. V. C. ; Tristao, A. ; Del Nero, U. ; Mendonca, M. ; Witkin, S. S. ; Sartorao Filho, I, C. ; Nuens, S. K. ; Pinheiro, F. A. ; Quiroz, V, S. ; Pascon, T. ; Caldeirao, T. D. ; Oliveira, A. P. ; Nicolosi, B. F. ; Bolognani, V, C. ; Fagundes, D. L. G. ; Llanos, I. C. F. ; Vernini, J. M. ; Reis, L. B. S. M. ; Sirimarco, M. P. ; Basso, N. M. ; Maquesim, N. A. Q. ; Silva, S. A. L. C. ; Silva, S. C. ; Scudeller, T. T. ; Ayach, W. ; Almeida, A. P. M. ; Nicolosi, B. F. C. A. ; Lima, C. P. ; Luminoso, D. ; Vasconcellos, F. C. ; Ferraz, G. A. R. ; Migiolaro, H. ; Camargo, L. P. ; Macedo, M. L. S. ; Rodrigues, M. R. K. ; Anezio, P. H. O. ; Grp, Perinatal Diabet Res
Número total de Autores: 91
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, Botucatu Med Sch FMB, Dept Gynecol & Obstet, UNESP, BR-18618687 Botucatu, SP - Brazil
[2] Sao Paulo State Univ, Botucatu Med Sch FMB, Grad Program Gynecol Obstet & Mastol, UNESP, Sao Paulo - Brazil
[3] Sao Paulo State Univ, Sch Philosophy & Sci, Dept Physiotherapy & Occupat Therapy, UNESP, Marilia, SP - Brazil
[4] Pontificia Univ Catolica Chile, Fac Med, Sch Med, Dept Obstet, Div Obstet & Gynaecol, CMPL, Santiago 8330024 - Chile
[5] Univ Seville, Fac Pharm, Dept Physiol, E-41012 Seville - Spain
[6] Univ Queensland, UQCCR, Fac Med & Biomed Sci, Herston, Qld 4029 - Australia
[7] Sao Paulo State Univ, Botucatu Med Sch FMB, Dept Pathol, UNESP, Sao Paulo - Brazil
[8] Sao Paulo State Univ, Biosci Inst, Biostat Dept, UNESP, Sao Paulo - Brazil
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE; v. 1866, n. 2 FEB 1 2020.
Citações Web of Science: 2
Resumo

Mild gestational hyperglycemia (MGH), as assessed using the normal oral glucose tolerance test (OGTT) and detection of an altered glycemic profile, is associated with adverse perinatal outcome. This study described the results of 40 years of research conducted at the Perinatal Diabetes Research Centre at Sao Paulo State University (UNESP), Brazil, on the maternal MGH environment and placental markers. This study also described the unidirectional relationship between MGH and excessive fetal growth, also supplying moderator analysis. In addition to hyperglycemia, MGH is associated with an increased incidence of hypertension, metabolic syndrome, persistent insulin resistance after pregnancy, and high risk of developing type 2 diabetes mellitus (T2DM) after pregnancy. Structural changes and functional abnormalities resulting from MGH were observed in placenta. The fully adjusted model concluded that the predictor variable (MGH), which creates a complex environment for the fetus, has a direct effect on excessive birth weight and produces a z-score for ratios of birth weight to gestational age of >= 2. Maternal age, pre-pregnancy BMI, number of previous pregnancies, numbers of prenatal visits, and 1 h OGTT are moderator variables that impact MGH and excessive fetal growth. These results show that maternal MGH has some characteristics associated with similar long-term T2DM development and similar adverse perinatal results to those of gestational diabetes mellitus (GDM) mothers, making it an intermediate maternal and placental marker between normoglycemic and GDM mothers. (AU)

Processo FAPESP: 16/01743-5 - Coorte da tríade gestacional: hiperglicemia, incontinência urinária e perfil clínico, molecular e ômico da miopatia hiperglicêmica na predição de incontinência e disfunção muscular e pesquisa translacional com biodevice para regeneração muscular em ratas
Beneficiário:Marilza Vieira Cunha Rudge
Modalidade de apoio: Auxílio à Pesquisa - Temático