Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy

Autor(es)

Nogueira, Mateus Henrique ^{[1, 2]} ; Pimentel da Silva, Luciana Ramalho ^{[1, 2]} ; Vasques Moreira, Jose Carlos ^{[1, 2]} ; Ribeiro de Rezende, Thiago Junqueira ^{[2, 3]} ; Zanao, Tamires Araujo ^{[1, 2]} ; de Campos, Brunno Machado ^{[1, 2]} ; Yasuda, Clarissa Lin ^{[1, 2]} ; Cendes, Fernando ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Dept Neurol, Lab Neuroimaging, Campinas - Brazil

^[2] Univ Campinas UNICAMP, Brazilian Inst Neurosci & Neurotechnol BRAINN, Campinas - Brazil

^[3] Univ Campinas UNICAMP, Lab Med Phys, Campinas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN NEUROLOGY; v. 10, JAN 17 2020.
• Citações Web of Science: 0

Resumo

Background: Major Depressive Disorder (MDD) is highly prevalent in patients with mesial temporal lobe epilepsy (MTLE), especially in women, carrying significant morbidity. This study aimed to investigate the cortical thickness (CT) abnormalities associated with MDD in women with MTLE and hippocampal atrophy (HA). Also, we investigated the impact of MDD upon the volumes of the hippocampus and amygdala in these patients. Methods: We included 50 women with MTLE and HA (20 left, LMTLE; 30 right, RMTLE), 41 healthy women in the control group, and 15 women with MDD without epilepsy. MTLE patients were subdivided into three groups: MTLE-without-MDD (23 MTLE patients without MDD), MTLE-mild-MDD (nine MTLE patients with mild symptoms of MDD), and MTLE-severe-MDD (18 MTLE patients with moderate to severe symptoms of MDD). The five groups were balanced for age (p = 0.56). All participants had high-resolution 3D T1-weighted images in a 3T scanner. We used FreeSurfer 6.0 for volumetry and CT parcellation. All participants were submitted to a clinical psychological evaluation through the Structured Clinical Interview for DSM-IV (SCID-IV) and completed the Beck Depression Inventory (BDI-II). Results: We identified a smaller ipsilateral amygdala volume (p = 0.04) in the MTLE-severe-MDD group when compared to the control group. Our results presented a reduced ipsilateral lateral orbitofrontal cortex (p = 0.02) in the MTLE-severe-MDD in comparison to the MTLE-mild-MDD group. We also identified a thinner ipsilateral fusiform gyrus (p < 0.01) in the MTLE-severe-MDD compared to both MTLE-without-MDD and control groups. A reduced CT of the contralateral superior frontal gyrus (p = 0.02) was observed in the MTLE-severe-MDD in comparison to the MTLE-mild-MDD group. Conclusions: The identification of areas with reduced CT and atrophy of the ipsilateral amygdala in women with MTLE and MDD suggest that the cortical thinning in the network of the paralimbic system is related to the co-occurrence and intensity of depressive symptoms in this group. (AU)

• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/08765-9 - Transtornos psiquiátricos na epilepsia: uma perspectiva clínica, laboratorial e morfológica
• Beneficiário: Mateus Henrique Nogueira
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 11/21818-6 - Transtornos de humor e de ansiedade na epilepsia: uma perspectiva clínica, laboratorial e morfológica
• Beneficiário: Mateus Henrique Nogueira
• Modalidade de apoio: Bolsas no Brasil - Doutorado