L-Glutamine Supplementation Improves the Benefits of Combined-Exercise Training on Oral Redox Balance and Inflammatory Status in Elderly Individuals

Autor(es):Mostrar menos -

Almeida, Ewin B. ^[1] ; Santos, Juliana M. B. ^[1] ; Paixao, Vitoria ^[1] ; Amaral, Jonatas B. ^[1] ; Foster, Roberta ^[1] ; Sperandio, Adriane ^{[2, 1]} ; Roseira, Tamaris ^{[2, 1]} ; Rossi, Marcelo ^[1] ; Cordeiro, Telma G. ^[1] ; Monteiro, Fernanda R. ^{[2, 1]} ; Amirato, Gislene R. ^[1] ; Santos, Carlos A. F. ^[1] ; Vieira, Rodolfo P. ^{[3, 4, 5, 6]} ; Vaisberg, Mauro ^[1] ; Barros, Marcelo ^[7] ; Bachi, Andre L. L. ^{[3, 2, 4, 1]}

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, ENT Lab, Dept Otorhinolaryngol, Rua Otonis 700, Second Floor, BR-04025002 Sao Paulo, SP - Brazil

^[2] Method Fac Sao Paulo FAMESP, Av Jabaquara 1314, BR-04046200 Sao Paulo, SP - Brazil

^[3] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos, SP - Brazil

^[4] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, Rua Carolina Fonseca 584, BR-08230030 Sao Paulo, SP - Brazil

^[5] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human & Rehabil, Av Ana Costa 95, BR-11060001 Santos, SP - Brazil

^[6] Anhembi Morumbi Univ, Sch Med, Av Dep Benedito Matarazzo 6070, BR-12230002 Sao Jose Dos Campos, SP - Brazil

^[7] Cruzeiro do Sul Univ, Inst Phys Act Sci & Sports ICAFE, Interdisciplinaty Postgrad Program Hlth Sci, Rua Galvao Bueno 868, BR-01506000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY; v. 2020, JAN 22 2020.
• Citações Web of Science: 0

Resumo

Although regular combined aerobic-resistance exercises can ameliorate the inflammatory status and redox balance in elderly population, it is unclear whether protein or specific amino acid supplementation could improve such benefits. Therefore, we aimed to evaluate the inflammatory status and redox indexes through of the saliva of 34 elderly subject nonpractitioners (NP group, 73:3 +/- 6:6 years) and 49 elderly subject practitioners of a combined-exercise training in moderate intensity (CET group, 71:9 +/- 5:8 years) before (pre) and after (post) 30 days of supplementation with L-glutamine (Gln) or placebo (PL). Our results showed that, both in pre- and postsupplementation, the salivary levels of nitric oxide (NO center dot) and TNF-alpha were lower, whereas the levels of uric acid and IL-10 (as well as IL-10/TNF-alpha ratio) were higher in the CET groups than in the NP groups. In postsupplementation, both groups supplemented with Gln (NP-Gln and CET-Gln) showed higher salivary uric acid levels compared to baseline. In addition, lower NO levels were found in the CET-Gln group postsupplementation than presupplementation values. Whereas the CET-Gln group showed lower GSH levels postsupplementation, NP-Gln subjects showed lower GSSG levels at the same time point, both compared to baseline. Interestingly, salivary peroxidase activity was lower only in NP groups (NP-PL and NP-Gln) postsupplementation than baseline values. A positive significant correlation between salivary peroxidase activity and GSH levels, and also between salivary peroxidase activity and uric acid levels were observed in the CET-Gln group both pre- and postsupplementation. No differences were found in albumin, total antioxidant activity (TEAC), and reducing power analysis between groups, pre- or postsupplementation. In conclusion, the elderly subjects from the CET group showed a better inflammatory response and redox balance and, for the first time, it was shown that daily supplementation with Gln for 30 days can improve these benefits with putative association with a healthy aging. (AU)

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