Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach

Autor(es)

Teixeira, Juliana Araujo ^[1] ; Steluti, Josiane ^[1] ; Gorgulho, Bartira Mendes ^[1] ; Ferreira Carioca, Antonio Augusto ^{[1, 2]} ; Alencar, Gizelton Pereira ^[1] ; Fisberg, Regina Mara ^[1] ; Marchioni, Dirce Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP - Brazil

^[2] Univ Fortaleza, Discipline Nutr, A Washington Soares 1321, BR-60811905 Fortaleza, Ceara - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF NUTRITION; v. 59, n. 1, p. 81-91, FEB 2020.
• Citações Web of Science: 0

Resumo

Purpose A structural equation model (SEM) was used to test multiple and simultaneous relationships between socio-demographic factors, dietary patterns, biochemical levels of folate, vitamin B12, docosahexaenoic acid (DHA), and its effects on homocysteine (Hcy) level. Methods Socio-demographic and lifestyle characteristics, blood sample, anthropometric measurements, and a food-frequency questionnaire (FFQ) were obtained from 281 individuals of ISA-Capital study (Sao Paulo, Brazil). The dietary patterns (DP) were estimated using factor analysis with principal component's estimation based on the frequency of daily intake derived from the 38-item FFQ. The SEM considered a theoretical model where the DP were expected to be directly associated with Hcy level, and indirectly via biochemical levels of folate, vitamin B12, and DHA. The variables sex, age, ethnicity, and MTHFR C677T polymorphism were included in the model. Results The Prudent DP (- 0.12, p = 0.04) had a negative effect, while MTHFR C677T polymorphism (0.16, p = 0.01), age (0.22, p < 0.01), and being man (0.16, p = 0.01) had a positive effect on Hcy level. There were no indirect effects of any dietary patterns on Hcy level, neither via folate, vitamin B12, nor DHA. DHA was negatively associated with the Modern DP (- 0.12, p = 0.04) and positively associated with the Prudent DP (0.19, p < 0.01). Conclusions The DP mainly composed of fruits and vegetables, natural juices, potato/cassava/cooked cornmeal, fish, and chicken, which was negatively associated with the Hcy level in this population. These findings support the role of a healthy dietary pattern in health outcomes, rather than promoting specific foods or nutrients, for policy-based health promotion strategies. (AU)

• Processo FAPESP: 14/12647-1 - Evidências sobre a relação entre metabolismo do folato e carbono-1 e três desfechos de importância em saúde: baixo peso ao nascer, persistência da infecção por HPV em homens e fatores de risco para doenças cardiovasculares
• Beneficiário: Juliana Araujo Teixeira
• Modalidade de apoio: Bolsas no Brasil - Doutorado