The role of water on the electronic transport in graphene nanogap devices designed for DNA sequencing

Autor(es)

Martins, Ernane de Freitas ^{[1, 2]} ; Amorim, Rodrigo G. ^[3] ; Feliciano, Gustavo Troiano ^[4] ; Scheicher, Ralph Hendrik ^[5] ; Rocha, Alexandre Reily ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Phys, Sao Paulo, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Theoret Phys, Campus Sao Paulo, Sao Paulo - Brazil

^[3] Univ Fed Fluminense, Dept Fis, ICEx, Volta Redonda, RJ - Brazil

^[4] Sao Paulo State Univ UNESP, Inst Chem, Campus Araraquara, Araraquara, SP - Brazil

^[5] Uppsala Univ, Dept Phys & Astron, Div Mat Theory, SE-75120 Uppsala - Sweden

• Tipo de documento: Artigo Científico
• Fonte: Carbon; v. 158, p. 314-319, MAR 2020.
• Citações Web of Science: 0

Resumo

Innovative methodologies for reliably and inexpensively sequencing DNA can lead to a new era of personalized medicine. In this work, we performed a theoretical investigation of a nanogap-based all electronic DNA sequencing device. To do so, we used a nitrogen-terminated nanogap on a graphene sheet with the aqueous environment fully taken into account. Our investigation is performed using a hybrid methodology combining quantum and classical mechanics coupled to non-equilibrium Green's functions for solving the electron transport across the device. The obtained results show that the DNA nucleotides can be both detected and distinguished in such a device, which indicates that it can be used as a DNA sequencing device providing very high sensitivity and selectivity. Furthermore, our results show that water plays a major role in electronic transport in nanoscopic tunneling devices, not only from an electrostatics point of view, but also by providing states that significantly increase the conductance in nanogap-based DNA sequencing devices. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 17/02317-2 - Interfaces em materiais: propriedades eletrônicas, magnéticas, estruturais e de transporte
• Beneficiário: Adalberto Fazzio
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/01343-7 - ICTP Instituto Sul-Americano para Física Fundamental: um centro regional para física teórica
• Beneficiário: Nathan Jacob Berkovits
• Modalidade de apoio: Auxílio à Pesquisa - Projetos Especiais