Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

Autor(es)

Teixeira, Giovana Rampazzo ^{[1, 2, 3]} ; Mendes, Leonardo Oliveira ^{[4, 5]} ; Veras, Allice Santos Cruz ^[1] ; Thorpe, Hayley Hope Allyssa ^[6] ; Favaro, Wagner Jose ^[7] ; de Almeida Chuffa, Luiz Gustavo ^[8] ; Pinheiro, Patricia Fernanda Felipe ^[8] ; Martinez, Francisco Eduardo ^[8]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Postgrad Program Movement Sci, Presidente Prudente, SP - Brazil

^[2] Univ Estadual Paulista, Sch Sci & Technol, Dept Physiotherapy, Campus Presidente Prudente, Sao Paulo, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Multictr Grad Program Physiol Sci, SBFis, Aracatuba, SP - Brazil

^[4] Univ Western Sao Paulo UNOESTE, Postgrad Program Anim Sci, Presidente Prudente, SP - Brazil

^[5] Univ Western Sao Paulo UNOESTE, Postgrad Program Hlth Sci, Presidente Prudente, SP - Brazil

^[6] Univ Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON - Canada

^[7] State Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil

^[8] Sao Paulo State Univ, UNESP Inst Biosci, Dept Anat, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: LIPIDS IN HEALTH AND DISEASE; v. 19, n. 1 JAN 29 2020.
• Citações Web of Science: 0

Resumo

Background Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Methods Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Results Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. Conclusions In this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer. (AU)

• Processo FAPESP: 13/25927-0 - Efeitos do consumo de etanol e do treinamento físico resistido nos parâmetros bioquímicos, hormonais e imunohistoquímicos da próstata dorsolateral de ratos UChB
• Beneficiário: Verônica Alves de Menezes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 08/00479-6 - Influência do exercício físico resistido no metabolismo da próstata ventral de ratos UChB (bebedor voluntário de etanol a 10%)
• Beneficiário: Giovana Rampazzo Teixeira
• Modalidade de apoio: Bolsas no Brasil - Doutorado