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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Hypotensive effect of Eugenia dysenterica leaf extract is primarily related to its vascular action: The possible underlying mechanisms

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Autor(es):
Fidelis-de-Oliveira, Patricia [1] ; Aparecida-Castro, Samanta [1] ; Silva, Denise Brentan [2] ; de Melo Morais, Ingrid Beatriz [3] ; Martins de Miranda, Victor Hugo [1] ; de Gobbi, Juliana Irani [1] ; Nunes Canabrava, Hudson Armando [3] ; Bispo-da-Silva, Luiz Borges [3]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Dept Physiol, Inst Biosci, Botucatu, SP - Brazil
[2] Fed Univ Mato Grosso Sul UFMS, Lab Prod Nat & Espectrometria Massas LAPNEM, Campo Grande, MS - Brazil
[3] Fed Univ Uberlandia UFU, Dept Pharmacol, Inst Biomed Sci, Campus Umuarama, Uberlandia, MG - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Ethnopharmacology; v. 251, APR 6 2020.
Citações Web of Science: 1
Resumo

Ethnopharmacological relevance: Eugenia dysenterica (ED) leaves are used in Brazil to treat cardiac diseases; however, there are no scientific data describing the effects of this species on cardiac activity. Aim of the study: To investigate the effect of ED aqueous leaf extract (EDLE) on hear rate (HR) and mean arterial pressure (MAP) of anaesthetised rats and its underlying mechanism of action. Material and methods: EDLE was analysed, and its proanthocyanidin composition was determined. After performing dose-effect curves for EDLE on HR and MAP, EDLE-induced hypotension was evaluated before and after atropine (AT), L-N(omega)-nitro-L-arginine methyl ester (L-NAME), hexamethonium (HXT), indomethacin (IND), carbenoxolone (CBX), or nifedipine (NFD) administration. The effect of proanthocyanidin-depleted extract (EDLE/P-) was also determined and compared to that of the EDLE with proanthocyanidins. Results: EDLE decreased the MAP in a dose-dependent manner; HR was decreased only with the highest and most toxic dose. Only CBX and NFD decreased EDLE-induced hypotension. Five polymeric series of proanthocyanidins were identified, which were mainly constituted by procyanidin and prodelphinidin units with B-type linkage and up to 12 flavan-3-ol units. EDLE/P- induced hypotension did not differ from that induced by EDLE. Conclusions: The cardiovascular effects of EDLE were primarily related to its vascular action. EDLE-induced hypotensive effect appeared to involve L-type calcium channel blockage as well as myoendothelial gap junction signalling. The higher molecular weight proanthocyanidins from EDLE are unlikely to contribute to its cardiovascular effect. (AU)

Processo FAPESP: 13/18382-7 - Avaliação dos efeitos de extrato aquoso liofilizado das folhas de Eugenia dysenterica DC sobre o sistema cardiovascular
Beneficiário:Samanta Aparecida Castro
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica