Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition

Autor(es)

Alice Batistuzzo ^[1] ; Miriam Oliveira Ribeiro ^[2]

Afiliação do(s) autor(es)

^[1] Universidade Presbiteriana Mackenzie. Centro de Ciências Biológicas e da Saúde. Departamento de Pós-Graduação em Distúrbios do Desenvolvimento - Brasil

^[2] Universidade Presbiteriana Mackenzie. Centro de Ciências Biológicas e da Saúde. Departamento de Pós-Graduação em Distúrbios do Desenvolvimento - Brasil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 64, n. 1, p. 89-95, 2020-03-13.

Resumo

ABSTRACT Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents. Arch Endocrinol Metab. 2020;64(1):89-95 (AU)

• Processo FAPESP: 17/18277-0 - Correlação entre o polimorfismo Thr92Ala da enzima iodotironina desiodase do tipo 2 (D2) e comportamento.
• Beneficiário: Miriam Oliveira Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular