Tuning the release profile of ketoprofen from poly(L-lactic acid) suture using supercritical CO2 impregnation process

Autor(es)

Champeau, Mathilde ^[1] ; Coutinho, Isabela Trindade ^[1] ; Thomassin, Jean-Michel ^[2] ; Tassaing, Thierry ^[3] ; Jerome, Christine ^[2]

Afiliação do(s) autor(es)

^[1] Fed Univ ABC, Ctr Engn Modeling & Appl Social Sci, BR-09210580 Santo Andre, SP - Brazil

^[2] Univ Liege, CERM, CESAM RU, Sart Tilman B6A, B-4000 Liege - Belgium

^[3] Univ Bordeaux, CNRS, UMR 5255, Inst Sci Mol, Grp Spectroscopie Mol, 351 Cours Liberat, F-33405 Talence - France

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 55, FEB 2020.
• Citações Web of Science: 0

Resumo

Poly(c-lactic acid) (PLLA) fibers were impregnated with the anti-inflammatory drug ketoprofen by supercritical CO2 (scCO(2)) assisted impregnation process, to develop drug-eluting absorbable sutures. This work indicates the possibility to tune not only the drug loading but also the release profile of ketoprofen from PLLA by modifying the impregnation (temperature and pressure) and depressurization (temperature and rate) conditions. Different PLLA sutures that release ketoprofen during 3 days up to 3 months were obtained. The release was shown to be governed by two parameters: the degradation rate of PLLA, that increases with the drug impregnation, and the sutures free volume, that was created due to scCO(2) sorbed and was partially conserved during depressurization. The degradation rate and the tensile strength loss of the suture are accelerated by ketoprofen since it catalyzes PLLA acid hydrolysis. (AU)

• Processo FAPESP: 18/23902-3 - Desenvolvimento de uma metodologia para otimizar a impregnação assistida por CO2 supercrítico de polímeros com extratos naturais
• Beneficiário: Mathilde Julienne Gisele Champeau
• Modalidade de apoio: Auxílio à Pesquisa - Regular