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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tuning the release profile of ketoprofen from poly(L-lactic acid) suture using supercritical CO2 impregnation process

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Author(s):
Champeau, Mathilde [1] ; Coutinho, Isabela Trindade [1] ; Thomassin, Jean-Michel [2] ; Tassaing, Thierry [3] ; Jerome, Christine [2]
Total Authors: 5
Affiliation:
[1] Fed Univ ABC, Ctr Engn Modeling & Appl Social Sci, BR-09210580 Santo Andre, SP - Brazil
[2] Univ Liege, CERM, CESAM RU, Sart Tilman B6A, B-4000 Liege - Belgium
[3] Univ Bordeaux, CNRS, UMR 5255, Inst Sci Mol, Grp Spectroscopie Mol, 351 Cours Liberat, F-33405 Talence - France
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 55, FEB 2020.
Web of Science Citations: 0
Abstract

Poly(c-lactic acid) (PLLA) fibers were impregnated with the anti-inflammatory drug ketoprofen by supercritical CO2 (scCO(2)) assisted impregnation process, to develop drug-eluting absorbable sutures. This work indicates the possibility to tune not only the drug loading but also the release profile of ketoprofen from PLLA by modifying the impregnation (temperature and pressure) and depressurization (temperature and rate) conditions. Different PLLA sutures that release ketoprofen during 3 days up to 3 months were obtained. The release was shown to be governed by two parameters: the degradation rate of PLLA, that increases with the drug impregnation, and the sutures free volume, that was created due to scCO(2) sorbed and was partially conserved during depressurization. The degradation rate and the tensile strength loss of the suture are accelerated by ketoprofen since it catalyzes PLLA acid hydrolysis. (AU)

FAPESP's process: 18/23902-3 - Development of a methodology for the optimization of supercritical CO2-assisted impregnation of polymers with natural extracts
Grantee:Mathilde Julienne Gisele Champeau
Support Opportunities: Regular Research Grants