Applications of biosensors in Alzheimer's disease diagnosis

Autor(es)

Brazaca, Lais Canniatti ^[1] ; Sampaio, Isabella ^[1] ; Zucolotto, Valtencir ^[1] ; Janegitz, Bruno Campos ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sao Carlos Inst Phys, Nanomed & Nanotoxicol Grp, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Dept Nat Sci Math & Educ, BR-13600970 Araras, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Talanta; v. 210, APR 1 2020.
• Citações Web of Science: 0

Resumo

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive and irreversible cognitive decline. Currently, it affects 36 million people and due to population ageing it is estimated that in 2030 disease incidence will reach 60 million individuals. The precise diagnosis of AD is still a complex task, being mainly performed by cerebrospinal fluid (CSF) analysis or neuroimaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI). Despite being effective these techniques are expensive, time-consuming and not accessible for most part of the population. In this scenario biosensors are presented as promising alternatives for simple, rapid and low cost diagnosis of AD. In this revision we summarize the recent advances on biosensors that brings more accessibility to AD diagnosis. We introduce the most used biorecognition elements in miniaturized biosensing systems as well as AD biomarkers present in CSF, in plasma and in genetic material which can be used for disease identification even in early stages. The recent developed biosensors for AD diagnosis using optical, electrochemical and colorimetric techniques as well as their strategies and analytical performances are discussed. Advancements in signal amplification methodologies with nano-materials to increase biosensors sensitivity are also presented. This review highlights the potential of biosensors to be used as an accurate and portable tool to improve the early AD diagnosis. (AU)

• Processo FAPESP: 17/21898-6 - Novos dispositivos condutores para aplicação em sensores e biossensores eletroquímicos
• Beneficiário: Bruno Campos Janegitz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/21097-3 - Interações abelha-agricultura: perspectivas para a utilização sustentável
• Beneficiário: Osmar Malaspina
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 15/02623-0 - Novas Plataformas para o Diagnóstico Rápido e Precoce do Mal de Alzheimer
• Beneficiário: Laís Canniatti Brazaca
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/19750-3 - Explorando a detecção C4D para o desenvolvimento de biossensores microfluídicos inovadores e de baixo custo
• Beneficiário: Laís Canniatti Brazaca
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado