Essential Metabolic Routes as a Way to ESKAPE From Antibiotic Resistance

Autor(es)

Barra, Angelica Luana C. ^[1] ; Dantas, Livia de Oliveira C. ^[1] ; Morao, Luana Galvao ^[1] ; Gutierrez, Raissa F. ^[1] ; Polikarpov, Igor ^[1] ; Wrenger, Carsten ^[2] ; Nascimento, Alessandro S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PUBLIC HEALTH; v. 8, FEB 28 2020.
• Citações Web of Science: 0

Resumo

Antibiotic resistance is a worldwide concern that requires a concerted action from physicians, patients, governmental agencies, and academia to prevent infections and the spread of resistance, track resistant bacteria, improve the use of current antibiotics, and develop new antibiotics. Despite the efforts spent so far, the current antibiotics in the market are restricted to only five general targets/pathways highlighting the need for basic research focusing on the discovery and evaluation of new potential targets. Here we interrogate two biosynthetic pathways as potentially druggable pathways in bacteria. The biosynthesis pathway for thiamine (vitamin B1), absent in humans, but found in many bacteria, including organisms in the group of the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacter sp.) and the biosynthesis pathway for pyridoxal 5 `-phosphate and its vitamers (vitamin B6), found in S. aureus. Using current genomic data, we discuss the possibilities of inhibition of enzymes in the pathway and review the current state of the art in the scientific literature. (AU)

• Processo FAPESP: 15/13684-0 - Estudos estruturais e funcionais de enzimas que participam na síntese e degradação de carboidratos complexos
• Beneficiário: Igor Polikarpov
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/18173-0 - Mecanismos Envolvidos em Resistência a Antibióticos: Parede de Ácidos Teicóicos e Biofilmes como Alvos Moleculares
• Beneficiário: Alessandro Silva Nascimento
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/26722-8 - Drug discovery contra doenças infecciosas humanos
• Beneficiário: Carsten Wrenger
• Linha de fomento: Auxílio à Pesquisa - Temático