Acute effects of oxytocin in music performance anxiety: a crossover, randomized, placebo-controlled trial

Autor(es)

Sabino, Alini D. V. ^[1] ; Chagas, Marcos Hortes N. ^[2] ; Osorio, Flavia L. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch Ribeirao Preto, Ave Bandeirantes 3900, BR-14048900 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Sao Carlos, Ctr Biol & Hlth Sci, Sao Carlos - Brazil

^[3] CNPq, Natl Inst Sci & Technol INCT TM, Brasilia, DF - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Psychopharmacology; v. 237, n. 6 MAR 2020.
• Citações Web of Science: 0

Resumo

Rationale Individuals with music performance anxiety (MPA) present physical, behavioral, and cognitive manifestations of anxiety, in addition to information processing deficits, especially in facial emotion recognition (FER). Objectives To assess the effects of a single dose of intranasal oxytocin (24 IU) on FER in a sample of musicians with high and low MPA (primary outcome), as well as indicators of mood/anxiety and self-assessed performance (secondary outcomes). Methods Crossover, randomized, double-blind, placebo-controlled trial involving 43 male musicians with different levels of MPA. Participants completed a static facial emotion recognition task and self-rated mood and performance scales. Data were analyzed using ANOVA 2 x 0 for crossover trials and the Omnibus test (measure of separability between intervention and carryover effects). Results Only musicians with high MPA treated with oxytocin had a higher accuracy in the recognition of happiness (p < 0.03; d > 0.72). No effects of oxytocin were found on mood indicators or on self-perceived performance, regardless of MPA level. Conclusions The results indicate possible benefits of the acute treatment with oxytocin in MPA, which may improve the management of this common and disabling condition that affects professional musicians. The appropriate perception of positive feedback may increase confidence and feelings of social acceptance, reducing symptoms associated with the condition. The lack of effects on mood/anxiety and cognition may be explained by the context-dependent characteristic of the effects of oxytocin, since the experiment did not represent an actual situation of social threat. (AU)

• Processo FAPESP: 15/02848-2 - Ansiedade social e de performance musical: efeitos agudos da ocitocina e Ayahuasca na voz, no reconhecimento de expressões faciais e nos sintomas clínicos e cognitivos
• Beneficiário: Flávia de Lima Osório
• Modalidade de apoio: Auxílio à Pesquisa - Regular