Antimicrobial effect of a local release system containing metronidazole against a Porphyromonas gingivalis biofilm

Autor(es)

Re, A. C. S. ^[1] ; Ferreira, M. P. ^[2] ; Freitas, O. ^[2] ; Aires, C. P. ^[1]

Afiliação do(s) autor(es)

^[1] Sch Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Sao Paulo - Brazil

^[2] Sch Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Pharmazie; v. 74, n. 11, p. 665-666, NOV 2019.
• Citações Web of Science: 0

Resumo

The aim of this study was to evaluate a semi-solid system containing metronidazole (MDZ) in presence of challenging conditions for drug release, as well its antimicrobial effect against Porphyromonas gingivalis biofilm. Biofilms grown in culture medium were exposed to a formulation containing MDZ or its vehicle. After 24, 48, and 72 h, biofilm viability were analyzed while MDZ was quantified in culture medium and buffer solution (control). MDZ formulation reduced bacterial viability when compared to control groups. The vehicle formulation also affected bacterial viability in relation to control at all periods. Culture medium impaired MDZ release compared to buffer solution at 24 h. The semi-solid system reported herein is able to release MDZ and maintain its levels at concentrations that control viability of P. gingivalis in 1- to 3-day-old biofilms. (AU)

• Processo FAPESP: 12/15556-1 - Adequação e efeito de um sistema de liberação sustentada de fármaco na presença de biofilme patogênico
• Beneficiário: Ana Carolina dos Santos Ré
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 12/15423-1 - Adequação e efeito de um sistema de liberação sustentada de fármaco na presença de biofilme patogênico
• Beneficiário: Carolina Patrícia Aires Garbellini
• Modalidade de apoio: Auxílio à Pesquisa - Regular