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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial effect of a local release system containing metronidazole against a Porphyromonas gingivalis biofilm

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Re, A. C. S. [1] ; Ferreira, M. P. [2] ; Freitas, O. [2] ; Aires, C. P. [1]
Total Authors: 4
[1] Sch Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Sao Paulo - Brazil
[2] Sch Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Pharmazie; v. 74, n. 11, p. 665-666, NOV 2019.
Web of Science Citations: 0

The aim of this study was to evaluate a semi-solid system containing metronidazole (MDZ) in presence of challenging conditions for drug release, as well its antimicrobial effect against Porphyromonas gingivalis biofilm. Biofilms grown in culture medium were exposed to a formulation containing MDZ or its vehicle. After 24, 48, and 72 h, biofilm viability were analyzed while MDZ was quantified in culture medium and buffer solution (control). MDZ formulation reduced bacterial viability when compared to control groups. The vehicle formulation also affected bacterial viability in relation to control at all periods. Culture medium impaired MDZ release compared to buffer solution at 24 h. The semi-solid system reported herein is able to release MDZ and maintain its levels at concentrations that control viability of P. gingivalis in 1- to 3-day-old biofilms. (AU)

FAPESP's process: 12/15556-1 - Suitability and effect of a controlled drug release system in presence of patogenic biofilm
Grantee:Ana Carolina dos Santos Ré
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/15423-1 - Suitability and effect of a controlled drug release system in presence of patogenic biofilm
Grantee:Carolina Patrícia Aires
Support type: Regular Research Grants