Antimicrobial effect of a local release system containing metronidazole against a Porphyromonas gingivalis biofilm

Author(s)

Re, A. C. S. ^[1] ; Ferreira, M. P. ^[2] ; Freitas, O. ^[2] ; Aires, C. P. ^[1]

Affiliation

^[1] Sch Pharmaceut Sci Ribeirao Preto, Dept Phys & Chem, Sao Paulo - Brazil

^[2] Sch Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, Sao Paulo - Brazil

• Document type: Journal article
• Source: Pharmazie; v. 74, n. 11, p. 665-666, NOV 2019.
• Web of Science Citations: 0

Abstract

The aim of this study was to evaluate a semi-solid system containing metronidazole (MDZ) in presence of challenging conditions for drug release, as well its antimicrobial effect against Porphyromonas gingivalis biofilm. Biofilms grown in culture medium were exposed to a formulation containing MDZ or its vehicle. After 24, 48, and 72 h, biofilm viability were analyzed while MDZ was quantified in culture medium and buffer solution (control). MDZ formulation reduced bacterial viability when compared to control groups. The vehicle formulation also affected bacterial viability in relation to control at all periods. Culture medium impaired MDZ release compared to buffer solution at 24 h. The semi-solid system reported herein is able to release MDZ and maintain its levels at concentrations that control viability of P. gingivalis in 1- to 3-day-old biofilms. (AU)

• FAPESP's process: 12/15556-1 - Suitability and effect of a controlled drug release system in presence of patogenic biofilm
• Grantee: Ana Carolina dos Santos Ré
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 12/15423-1 - Suitability and effect of a controlled drug release system in presence of patogenic biofilm
• Grantee: Carolina Patrícia Aires Garbellini
• Support Opportunities: Regular Research Grants