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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Interactions between in vivo neuronal-glial markers, side of hippocampal sclerosis, and pharmacoresponse in temporal lobe epilepsy

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Autor(es):
Pimentel-Silva, Luciana R. [1] ; Casseb, Raphael F. [1] ; Cordeiro, Monica M. [1] ; Campos, Bruno A. G. [1] ; Alvim, Marina K. M. [1] ; Rogerio, Fabio [2] ; Yasuda, Clarissa L. [1] ; Cendes, Fernando [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Neurol, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Dept Pathol, Campinas - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Epilepsia; v. 61, n. 5 APR 2020.
Citações Web of Science: 0
Resumo

Objective To evaluate the interactions of metabolic neuronal-glial changes with the presence and hemispheric-side of hippocampal sclerosis (HS) and its potential role in predicting pharmacoresistance in temporal lobe epilepsy (TLE). Methods We included structural magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (H-1-MRS) metabolic data for 91 patients with unilateral TLE and 50 healthy controls. We measured the values of total N-acetyl aspartate/total creatine (tNAA/tCr), glutamate/tCr (Glu/tCr), and myo-inositol/tCr (mIns/tCr). To assess the influence of the pharmacoresponse and hemispheric-side of HS on metabolic data, the relationship between clinical and MRI data, and the predictive value of NAA/Cr, we used analysis of variance/covariance and built a logistic regression model. We used bootstrap simulations to evaluate reproducibility. Results Bilateral tNAA/tCr reduction was associated with pharmacoresistance and with left HS, a decrease of Glu/tCr ipsilateral to the seizure focus was associated with pharmacoresistance, and ipsilateral mIns/tCr increase was related to pharmacoresistance and the presence of left HS. The logistic regression model containing clinical and H-1-MRS data discriminated pharmacoresistance (area under the curve {[}AUC] = 0.78). However, the reduction of tNAA/tCr was the main predictor, with the odds 2.48 greater for pharmacoresistance. Significance Our study revealed a spectrum of neuronal-glial changes in TLE, which was associated with pharmacoresistance, being more severe in left-sided HS and less severe in MRI-negative TLE. These noninvasive, in vivo biomarkers provide valuable additional information about the interhemispheric differences in metabolic dysfunction, seizure burden, and HS, and may help to predict pharmacoresistance. (AU)

Processo FAPESP: 13/21056-4 - Estudo de espectrocospia de prótons por ressonância magnética para determinação de biomarcadores inflamatórios e de refratariedade em epilepsia do lobo temporal
Beneficiário:Luciana Ramalho Pimentel da Silva
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/15918-6 - Avaliação do padrão de ativação motora de pacientes com neuronopatias sensitivas utilizando fMRI e conectividade efetiva
Beneficiário:Raphael Fernandes Casseb
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
Beneficiário:Fernando Cendes
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs