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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Global Distribution and Evolution of Mycobacterium bovis Lineages

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Autor(es):
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Zimpel, Cristina Kraemer [1, 2] ; Patane, Jose Salvatore L. [3, 4] ; Proenga Guedes, Aureliano Coelho [5] ; de Souza, Robson F. [5] ; Silva-Pereira, Taiana T. [1, 2] ; Soler Camargo, Naila C. [1, 2] ; de Souza Filho, Antonio F. [1] ; Ikuta, Cassia Y. [1] ; Ferreira Neto, Jose Soares [1] ; Setubal, Joao Carlos [3, 6] ; Heinemann, Marcos Bryan [1] ; Sa Guimaraes, Ana Marcia [2]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Prevent Vet Med & Anim Hlth, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Appl Res Mycobacteria, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo - Brazil
[4] Butantan Inst, Lab Cellular Cycle, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Lab Prot Struct & Evolut, Dept Microbiol, Sao Paulo - Brazil
[6] Virginia Tech, Biocomplex Inst, Blacksburg, VA - USA
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN MICROBIOLOGY; v. 11, MAY 7 2020.
Citações Web of Science: 1
Resumo

Mycobacterium bovis is the main causative agent of zoonotic tuberculosis in humans and frequently devastates livestock and wildlife worldwide. Previous studies suggested the existence of genetic groups of M. bovis strains based on limited DNA markers (a.k.a. clonal complexes), and the evolution and ecology of this pathogen has been only marginally explored at the global level. We have screened over 2,600 publicly available M. bovis genomes and newly sequenced four wildlife M. bovis strains, gathering 1,969 genomes from 23 countries and at least 24 host species, including humans, to complete a phylogenomic analyses. We propose the existence of four distinct global lineages of M. bovis (Lb1, Lb2, Lb3, and Lb4) underlying the current disease distribution. These lineages are not fully represented by clonal complexes and are dispersed based on geographic location rather than host species. Our data divergence analysis agreed with previous studies reporting independent archeological data of ancient M. bovis (South Siberian infected skeletons at similar to 2,000 years before present) and indicates that extant M. bovis originated between 715 and 3,556 years BP, with later emergence in the New World and Oceania, likely influenced by trades among countries. (AU)

Processo FAPESP: 17/04617-3 - Adaptação de Mycobacterium tuberculosis e Mycobacterium bovis a hospedeiros: uma análise genômica e transcricional
Beneficiário:Cristina Kraemer Zimpel
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/20147-7 - Investigação da taxa de pseudogenização entre genomas do complexo Mycobacterium tuberculosis
Beneficiário:Naila Cristina Soler Camargo
Linha de fomento: Bolsas no Brasil - Iniciação Científica