Aggregatibacter actinomycetemcomitans serotypes and JP2 outcomes related to clinical status over 6 years under periodontal maintenance therapy

Autor(es)

Cortelli, Jose Roberto ^[1] ; Cortelli, Sheila Cavalca ^[1] ; Aquino, Davi Romeiro ^[1] ; Miranda, Tais Browne ^[2] ; Moreira Jardim, Joao Carlos ^[2] ; Costa, Fernando de Oliveira ^[3]

Afiliação do(s) autor(es)

^[1] Univ Taubate, Sch Dent, Nucleus Periodontal Res, Taubate, SP - Brazil

^[2] Univ Taubate, Sch Dent, Taubate, SP - Brazil

^[3] Univ Fed Minas Gerais, Sch Dent, Periodontal Dept, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 116, AUG 2020.
• Citações Web of Science: 0

Resumo

Objective: This 6-year study evaluated Aggregatibacter actinomycetemcomitans outcomes and their relationship to clinical status. Design: From the eligible individuals (23-70 years of age), 31 regular compliers (between-visit interval <= 6 months) were randomly selected and matched for age/sex with 31 irregular compliers (between-visit interval > 6 months). Periodontal clinical examination and subgingival samples were obtained 5 times: T1 (baseline), T2 (after active periodontal therapy), T3 (2 years), T4 (4 years), and T5 (6 years). Total bacteria load, A. actinomycetemcomitans, and red complex species Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola levels were determined by qPCR while PCR was used to determine the occurrence of the a-b-c-d-e-f-g serotypes and the JP2 clone of A. actinomycetemcomitans. Data between groups was compared over time. Results: At baseline PCR revealed A. actinomycetemcomitans prevalence of 9.7 % and JP2 prevalence of 6.7 %. A. actinomycetemcomitans qPCR levels were higher among individuals <= 35 years of age and increased at T2 in irregular compliers. At in irregular compliers at the three follow-up visits. Serotypes a, d, and f showed greater values in at least one follow-up visit in regular compliers. A. actinomycetemcomitans showed negative correlation with probing depth (PD) while serotype b showed negative correlations with PD, PI, clinical attachment level and red complex. Conclusions: Longitudinally, compliance during PMT contributed to lower A. actinomycetemcomitans levels with some degree of correlation with clinical status. However, this study failed to report any positive effect on the occurrence of the most virulent representatives, i.e. serotype b and the JP2 clone. (AU)

• Processo FAPESP: 16/15999-1 - Avaliação do efeito da Terapia de Manutenção Periodontal por meio de parâmetros clínicos e microbianos em uma coorte prospectiva de 6 anos
• Beneficiário: José Roberto Cortelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular