Antitumor activity of Pd(II) complexes with N,S or O,S coordination modes of acylthiourea ligands

Autor(es):Mostrar menos -

Plutin, Ana M. ^[1] ; Ramos, Raul ^{[1, 2]} ; Mocelo, Raul ^{[1, 2]} ; Alvarez, Anislay ^{[1, 2]} ; Castellano, Eduardo E. ^[3] ; Cominetti, Marcia R. ^[4] ; Oliveira, Katia M. ^[5] ; de Oliveira, Tamires Donizeth ^[5] ; Silva, Thales E. M. ^[6] ; Correa, Rodrigo S. ^[7] ; Batista, Alzir A. ^[5]

Afiliação do(s) autor(es)

^[1] Univ La Habana, Fac Quim, Lab Sintesis Organ, Havana - Cuba

^[2] Correa, Rodrigo S., Univ Fed Ouro Preto, Dept Quim, Ouro Preto, MG, Brazil.Plutin, Ana M., Univ La Habana, Fac Quim, Lab Sintesis Organ, Havana - Cuba

^[3] Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP - Brazil

^[4] Univ Fed Sao Carlos, Dept Gerontol, Sao Carlos, SP - Brazil

^[5] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil

^[6] Univ Fed Alfenas, Pocos De Caldas, MG - Brazil

^[7] Univ Fed Ouro Preto, Dept Quim, Ouro Preto, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Polyhedron; v. 184, JUL 1 2020.
• Citações Web of Science: 0

Resumo

Seven new complexes (1-7) of Pd(II) with N-alkyl- and N,N-dialkyl-N'-acylthioureas were prepared and characterized by elemental analysis and spectroscopic techniques. The crystal structures of the coordination compounds {[}PdCl(PPh3)(5-cloropiridyl-N'-benzoylthioureato-k(2)N,S)] (2), cis-{[}Pd(PPh3)(2)(N-morpholyn-N'-benzoylthioureato-k(2)O,S)]PF6 (4) and cis-{[}Pd(PPh3)(2)(N,N-diphenyl-N'-thiophenylthioureato-k(2)O,S)]PF6 (7) were determined by X-ray crystallography. The present study reports on an interesting contribution on the chemistry of Pd(II)/acylthiourea complexes, where the use of monosubstituted acylthiourea conducts to formation of neutral complexes with general formula {[}Pd(Cl)(PPh3)(acylthiourea)], with a N,S-coordination mode. On the other hand, cationic complexes with formula {[}Pd(PPh3)(2)(acylthiourea)](+), with O,S bidentately coordinated to the metal, are obtained by using a disubstituted acylthiourea derivative. The antitumor activity of the N-alkyl- and N,N-dialkyl-N'-acylthiourea ligands and their palladium (II) complexes with synthesized triphenylphosphine were evaluated against the growth of the DU-145 tumor cells (prostate cancer cells), (MDA-MB-231 (breast cancer cells), L929 (healthy mouse cells). The ligands are not cytotoxic, but the complexes showed good cytotoxicity against the tumor cells tested in this work, and were even better, when compared to the IC50 reported for the cisplatin. The complexes showed better activity results in MDA-MB-231 tumor cells, than for the DU-145 tumor cells. Complexes 1 and 6 showed high cytotoxic activity at low micromolar concentrations (IC50 = 1.93 +/- 0.45, 0.62 +/- 0.08 mu M) against MDA-MB-231 (human breast cancer cells). This result indicated that the binding of the ligands to the metal center increases their antitumor activity. (C) 2020 Published by Elsevier Ltd. (AU)

• Processo FAPESP: 18/19342-2 - Complexos metalicos com ligantes derivados da lausona e aciltioureas, com potenciais atividades anticancerígenas: estudos in vitro e in vivo
• Beneficiário: Alzir Azevedo Batista
• Modalidade de apoio: Auxílio à Pesquisa - Regular