Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes

Autor(es)

Neto, Jose S. S. ^[1] ; Balaguez, Renata A. ^[2] ; Franco, Marcelo S. ^{[1, 3]} ; de Sa Machado, Victor C. ^{[1, 3]} ; Saba, Sumbal ^[4] ; Rafique, Jamal ^[5] ; Galetto, Fabio Z. ^[2] ; Braga, Antonio L. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Fed Santa Catarina, LabSelen Dept Quim, BR-88040900 Florianopolis, SC - Brazil

^[2] Univ Fed Santa Catarina, Dept Quim, BR-88040900 Florianopolis, SC - Brazil

^[3] Rafique, Jamal, Univ Fed Mato Grosso UFMS, Inst Quim, BR-79074460 Campo Grande, MS, Brazil.Neto, Jose S. S., Univ Fed Santa Catarina, LabSelen Dept Quim, BR-88040900 Florianopolis, SC - Brazil

^[4] Univ Fed ABC, Ctr Ciencias Nat & Humanas CCNH, BR-09210580 Santo Andre, SP - Brazil

^[5] Univ Fed Mato Grosso UFMS, Inst Quim, BR-79074460 Campo Grande, MS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: GREEN CHEMISTRY; v. 22, n. 11, p. 3410-3415, JUN 7 2020.
• Citações Web of Science: 1

Resumo

Herein, we describe an efficient, rapid and benign protocol for the direct C(sp(2))-H bond halogenation (Cl, Br, I) of 2-arylimidazo{[}1,2-a]pyridines using trihaloisocyanuric acids in ethanol. Furthermore, this sustainable protocol was successfully extended to imidazopyrimidine, imidazothiazole and indazole heterocycles showing the broadness of this useful approach. (AU)

• Processo FAPESP: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Beneficiário: Arlene Gonçalves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Programa Centros de Pesquisa em Engenharia