Arginase and its mechanisms inLeishmaniapersistence

Autor(es)

Pessenda, Gabriela ^[1] ; da Silva, Joao Santana ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto - Brazil

^[2] Fundacao Oswaldo Cruz Bi Inst, Ribeirao Preto - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PARASITE IMMUNOLOGY; v. 42, n. 7, SI JUL 2020.
• Citações Web of Science: 0

Resumo

Leishmaniasis is a neglected infectious disease with clinical presentations ranging from asymptomatic or mild symptoms to chronic infection and eventual death. The mechanisms of disease susceptibility and pathology have been extensively studied, but there are no steadfast rules regarding leishmaniasis. A Th1 response is usually associated with infection control, while a predominant Th2 response is detrimental to the patient. In this scenario, the enzymes arginase and inducible nitric oxide synthase represent two possible pathways of immune response. While the former contributes to parasite replication, the latter is crucial for its control. In the present review, we collected study results that associate arginase expression in patients and in experimental models with disease susceptibility/chronicity and show some proposed mechanisms that explain the role of arginase in maintainingLeishmaniainfection, including polyamine and thiol synthesis, tissue-resident macrophage (TRM) proliferation and activation and T-cell suppression and exhaustion. (AU)

• Processo FAPESP: 17/09746-6 - O papel de macrófagos dermais na resposta imune inicial contra a infecção por Leishmania
• Beneficiário: Gabriela Pessenda
• Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 15/25289-9 - Identificação e validação de genes essenciais para a indução da resposta imune em pacientes com leishmaniose visceral
• Beneficiário: Gabriela Pessenda
• Linha de fomento: Bolsas no Brasil - Doutorado