Controlled Drug Delivery Vehicles in Veterinary Oncology: State-of-the-Art and Future Directions

Autor(es)

Lainetti, Patricia de Faria ^[1] ; Zuliani, Fernanda ^[1] ; Leis-Filho, Antonio Fernando ^[1] ; Fonseca Alves, Ricardo Henrique ^[2] ; Fonseca-Alves, Carlos Eduardo ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Surg & Anim Reprod, BR-18618681 Botucatu, SP - Brazil

^[2] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 - USA

^[3] Univ Paulista UNIP, Inst Hlth Sci, BR-17048290 Bauru, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PROCESSES; v. 8, n. 5 MAY 2020.
• Citações Web of Science: 0

Resumo

Controlled drug delivery systems can be used to carry several anticancer agents, including classical chemotherapeutic agents such as doxorubicin, paclitaxel or cisplatin, and are also used for the encapsulation of tyrosine kinase inhibitors and monoclonal antibodies. Usually, the controlled systems are used to decrease drug toxicity, increase local drug concentration or target specific organs or systems. In dogs, liposomal doxorubicin is the most known controlled drug delivery vehicle in veterinary medicine. However, several antitumor drugs can be encapsulated within these systems. Since the delivery vehicles are a relatively new topic in veterinary oncology, this review aims to discuss the current knowledge regarding the controlled drug delivery vehicles and discuss the current challenges and future direction of its use in veterinary oncology. (AU)

• Processo FAPESP: 15/25400-7 - Estudo para caracterização in vitro e molecular de células prostáticas caninas e avaliação da resposta antitumoral a drogas alvo dirigidas
• Beneficiário: Carlos Eduardo Fonseca Alves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/06278-4 - Sistema de distribuição controlada de fármacos na Oncologia Veterinária: estado da arte e orientações futuras
• Beneficiário: Carlos Eduardo Fonseca Alves
• Modalidade de apoio: Auxílio à Pesquisa - Publicações científicas - Artigo