Cholecystectomy - a potential selection bias in studies assessing the metabolic effects of bariatric surgeries

Autor(es)

Machado, Natasha Mendonca ^[1] ; Cardinelli, Camila de Siqueira ^[1] ; Shen, Tong ^[2] ; Santo, Marco Aurelio ^[3] ; Torrinhas, Raquel Susana ^[1] ; Waitzberg, Dan Linetzky ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Gastroenterol, Lab Nutr & Metab Surg Digest Tract LIM 35, Fac Med FMUSP, Sao Paulo, SP - Brazil

^[2] Univ Calif Davis, West Coast Metabol Ctr, Davis, CA 95616 - USA

^[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Digest Surg Dept, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 10, n. 1 JUN 30 2020.
• Citações Web of Science: 0

Resumo

Bile acids (BAs) are key mediators of the glycemic control after bariatric surgeries. Cholecystectomy modifies the kinetics of BAs, and whether this procedure influences the BAs pool and its metabolic response to bariatric surgeries is not known. We used targeted and untargeted metabolomics to assess whether cholecystectomy influenced plasma and fecal BAs fluctuations and the systemic metabolomic profile after Roux-en-Y gastric bypass (RYGB). Women with obesity and type 2 diabetes were included. Sample collections and clinical evaluations were performed before and 3 months after RYGB. RYGB influenced 9 fecal and 3 plasma BAs in patients with cholecystectomy (p <= 0.05). Comparisons between patients with and without cholecystectomy revealed different concentrations of 4 fecal and 5 plasma BAs (p <= 0.05). Cholecystectomy impacted the global metabolomics responses to RYGB, and patients who underwent the gallbladder removal also lacked some significant improvements in clinical markers, primarily the lipid profile. By affecting the BAs concentrations, cholecystectomy seems to alter the systemic metabolic response to RYGB. Therefore, cholecystectomy may act as a bias in assessments of the metabolic effects of bariatric surgeries and their relationships with clinical outcomes. (AU)

• Processo FAPESP: 16/01259-6 - Análise do perfil metabolômico de pacientes obesos portadores de diabetes melito tipo 2 após gastroplastia redutora a Y de Roux
• Beneficiário: Natasha Mendonça Machado
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 13/23355-9 - Análise do perfil metabolômico de pacientes obesos portadores de diabetes melito tipo 2 após gastroplastia redutora a y de roux
• Beneficiário: Natasha Mendonça Machado
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/09612-3 - Alterações na expressão gênica do tecido gástrico e intestinal de portadores de Diabetes melito tipo 2 submetidos à gastroplastia redutora a Y-Roux
• Beneficiário: Dan Linetzky Waitzberg
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/05220-1 - Metabolômica da água fecal de pacientes obesos com Diabetes tipo 2 antes e após gastroplastia redutora em Y-Roux (GRYR)
• Beneficiário: Camila de Siqueira Cardinelli
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto