Prostatic hyperplasia: Vascularization, hemodynamic and hormonal analysis of dogs treated with finasteride or orchiectomy

Autor(es)

Angrimani, Daniel S. R. ^[1] ; Francischini, Maria Claudia P. ^[1] ; Brito, Maira M. ^[1] ; Vannucchi, Camila I. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Vet Med, Dept Anim Reprod, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 15, n. 6 JUN 25 2020.
• Citações Web of Science: 0

Resumo

As a consequence of a hormonal imbalance, Prostatic Hyperplasia (PH) is characterized by increased prostate volume, along with higher local angiogenesis and vascularization. Orchiectomy is the common treatment for dogs, however it is not an option for breeding animals. Thus, finasteride arises as the drug of choice for stud dogs. Therefore, the aim of this study was to evaluate the effects of orchiectomy or finasteride therapies on hormonal and vascular dynamics of PH dogs. Fifteen dogs, aged 6-13 years were assigned to: Untreated Group (dogs diagnosed with PH-n = 5), Finasteride treated group (PH dogs treated with finasteride-n = 5) and Orchiectomy treated group (PH dogs submitted to orchiectomy-n = 5). Evaluations were performed in a monthly interval (first day of treatment; after 30 and 60 days). Doppler ultrasonography was performed to measure prostatic volume, vascularization and hemodynamic profile of prostatic artery. Dihydrotestosterone, estrogen and testosterone concentrations were measured. At day 60, prostatic biopsy was performed for histological, immunohistochemical and qPCR analysis forVEGF-Aexpression. At day 60, vascularization score was higher in untreated compared to treated groups (finasteride and orchiectomy). Furthermore,VEGF-Aexpression was lower in the Orchiectomy Treated Group, but VEGF-A was immunohistochemically lower in both treated groups (finasteride and orchiectomy) compared to the Untreated Group. The efficiency of finasteride treatment in reducing clinical signs, prostate volume and vascularization appears to be similar to orchiectomy. In conclusion, both PH medical and surgical therapy lead to reduction in prostate dimension andVEGF-Aexpression and, consequently, lower local vascularization. However, orchiectomy promotes marked hormonal changes, which ultimately lead to prostate atrophy. (AU)

• Processo FAPESP: 15/05419-5 - Senescência reprodutiva em cães: aspectos clínicos e biotecnológicos
• Beneficiário: Camila Infantosi Vannucchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/25966-5 - Caracterização seminal e das alterações hemodinâmicas da próstata e testículos de cães com hiperplasia prostática benigna
• Beneficiário: Daniel de Souza Ramos Angrimani
• Modalidade de apoio: Bolsas no Brasil - Doutorado