Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Autor(es)

Bravi, Francesca ^[1] ; Lee, Yuan-Chin Amy ^{[2, 3]} ; Hashibe, Mia ^{[2, 3]} ; Boffetta, Paolo ^{[4, 5]} ; Conway, David I. ^[6] ; Ferraroni, Monica ^[1] ; La Vecchia, Carlo ^[1] ; Edefonti, Valeria ^[1] ; Investigators, INHANCE Consortium

Afiliação do(s) autor(es)

^[1] Univ Milan, Dept Clin Sci & Community Hlth, Branch Med Stat Biometry & Epidemiol GA Maccacaro, Via Venezian 1, I-20133 Milan - Italy

^[2] Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT 84112 - USA

^[3] Huntsman Canc Inst, Salt Lake City, UT - USA

^[4] Univ Bologna, Dept Med & Surg Sci, Bologna - Italy

^[5] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY 11794 - USA

^[6] Univ Glasgow, Sch Med Dent & Nursing, Glasgow, Lanark - Scotland

• Tipo de documento: Artigo de Revisão
• Fonte: ORAL DISEASES; v. 27, n. 1 JUL 2020.
• Citações Web of Science: 1

Resumo

Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that similar to 30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies. (AU)

• Processo FAPESP: 10/51168-0 - Fatores ambientais, clínicos, histopatológicos e moleculares associados ao desenvolvimento e ao prognóstico de carcinomas epidermoides de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
• Beneficiário: José Eluf Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular