Resposta inflamatória in situ e morte neuronal em sistema nervoso central de casos...
- Auxílios pontuais (curta duração)
| Texto completo | |
| Autor(es): |
Santos, L. B.
[1]
;
Guedes, F.
[1]
;
Achkar, S. M.
[1]
;
Duarte, M. I. S.
[2]
;
Katz, I. S. S.
[1]
;
Silva, S. R.
[1]
;
Fernandes, E. R.
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Inst Pasteur, Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Disciplina Patol Molestias Transmissiveis, Fac Med, Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Neuroimmunology; v. 344, JUL 15 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
The Th17 profile immune response is influenced by the presence of cytokines such as IL-1, IL-6, TGF-beta, IL-17, and IL-23. We sought to characterize the Th17 profile in CNS samples from human rabies cases transmitted by dogs and examine its possible influence on disease pathogenesis. We observed a high expression of TGF-beta, followed by IL-23, IL-17 and IL-6, and a low expression of IL-1 beta and IFN-gamma. Those results suggest the participation of Th17 in rabies virus neuroinfection transmitted by dogs. IL-23 probably plays a role in maintaining the Th17 profile, but it can also interfere with the establishment of the Th1 profile and viral clearance. (AU) | |
| Processo FAPESP: | 14/10186-7 - Resposta inflamatória in situ e morte neuronal em sistema nervoso central de casos de raiva humana transmitida por cão |
| Beneficiário: | Elaine Raniero Fernandes |
| Linha de fomento: | Auxílio à Pesquisa - Regular |