Characterization of the Th17 profile immune response in cases of human rabies transmitted by dogs and its interference in the disease pathogenesis

Autor(es)

Santos, L. B. ^[1] ; Guedes, F. ^[1] ; Achkar, S. M. ^[1] ; Duarte, M. I. S. ^[2] ; Katz, I. S. S. ^[1] ; Silva, S. R. ^[1] ; Fernandes, E. R. ^[1]

Afiliação do(s) autor(es)

^[1] Inst Pasteur, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Lab Disciplina Patol Molestias Transmissiveis, Fac Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Neuroimmunology; v. 344, JUL 15 2020.
• Citações Web of Science: 0

Resumo

The Th17 profile immune response is influenced by the presence of cytokines such as IL-1, IL-6, TGF-beta, IL-17, and IL-23. We sought to characterize the Th17 profile in CNS samples from human rabies cases transmitted by dogs and examine its possible influence on disease pathogenesis. We observed a high expression of TGF-beta, followed by IL-23, IL-17 and IL-6, and a low expression of IL-1 beta and IFN-gamma. Those results suggest the participation of Th17 in rabies virus neuroinfection transmitted by dogs. IL-23 probably plays a role in maintaining the Th17 profile, but it can also interfere with the establishment of the Th1 profile and viral clearance. (AU)

• Processo FAPESP: 14/10186-7 - Resposta inflamatória in situ e morte neuronal em sistema nervoso central de casos de raiva humana transmitida por cão
• Beneficiário: Elaine Raniero Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Regular