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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Characterization of the Th17 profile immune response in cases of human rabies transmitted by dogs and its interference in the disease pathogenesis

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Author(s):
Santos, L. B. [1] ; Guedes, F. [1] ; Achkar, S. M. [1] ; Duarte, M. I. S. [2] ; Katz, I. S. S. [1] ; Silva, S. R. [1] ; Fernandes, E. R. [1]
Total Authors: 7
Affiliation:
[1] Inst Pasteur, Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Disciplina Patol Molestias Transmissiveis, Fac Med, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Neuroimmunology; v. 344, JUL 15 2020.
Web of Science Citations: 0
Abstract

The Th17 profile immune response is influenced by the presence of cytokines such as IL-1, IL-6, TGF-beta, IL-17, and IL-23. We sought to characterize the Th17 profile in CNS samples from human rabies cases transmitted by dogs and examine its possible influence on disease pathogenesis. We observed a high expression of TGF-beta, followed by IL-23, IL-17 and IL-6, and a low expression of IL-1 beta and IFN-gamma. Those results suggest the participation of Th17 in rabies virus neuroinfection transmitted by dogs. IL-23 probably plays a role in maintaining the Th17 profile, but it can also interfere with the establishment of the Th1 profile and viral clearance. (AU)

FAPESP's process: 14/10186-7 - In situ inflammatory response and neuronal death in central nervous system of cases of human rabies transmitted by dog
Grantee:Elaine Raniero Fernandes
Support Opportunities: Regular Research Grants