Evaluation of active immunity of primary vaccinated dog (Fuenzalida & Palacios) in the range of vaccination campaigns against rabies in the city of Botucatu/SP

• Grant number: 09/09098-8
• Support type: Regular Research Grants
• Duration: November 01, 2009 - October 31, 2011
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal researcher: José Rafael Módolo
• Grantee: José Rafael Módolo
• Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Rabies is a zoonosis of worldwide distribution, caused by a virus of the genus Lyssavirus transmitted to humans by inoculation of mammals by the rabies virus exists in the saliva of infected animal. After the onset of symptoms is fatal both to men and to animals. Worldwide, the dog is responsible for 99% of cases of human rabies and 92% of post-exposure treatments. Also in Brazil, the rabid dog is historically responsible for the deaths of 57% human. Died in the country, between 1999 and 2008,of rabies, 238 people, with 143 of those deaths attributed to this animal. The canine rabies has been controlled by mass immunization campaigns through annual vaccination of dogs which are, consequently, the best protection for human health. This prophylaxis is performed, continuously since 1968 in the city of Botucatu/SP is the first city of the state and have this mass vaccination. In order to evaluate the vaccine immunity in primary vaccinated dogs, this study will be conducted in two annual vaccination campaigns. The primary vaccinated dogs, totaling 400, will be randomly chosen during the 2009 campaign. The title of antibodies to rabies will be detected by the technique of Fluorescence Focus Inhibition of Fast - RFFIT. The serum titers found are tabulated for subsequent statistical analysis qualitatively, using the chi - square and coefficient of Yule. The variable is considered significant when p <0.05. (AU)