| Texto completo | |
| Autor(es): |
Abbasoglu, Zerrin
[1]
;
Dalledone, Mariana
[2]
;
Wambier, Leticia M.
[3]
;
Pecharki, Giovana
[4]
;
Baratto-Filho, Flares
[2, 5]
;
Andrades, Kesly Mary R.
[5]
;
Scariot, Rafaela
[2]
;
Trevilatto, Paula C.
[6]
;
Brancher, Joao A.
[2]
;
Kuchler, Erika C.
[2, 5]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Yeditepe Univ, Dept Pediat Dent, Istanbul - Turkey
[2] Univ Positivo, Sch Hlth & Biol Sci, R Prof Pedro Viriato Parigot de Souza, BR-5300 Curitiba, Parana - Brazil
[3] Univ Positivo, Sch Hlth & Biol Sci, Dept Dent, Curitiba, Parana - Brazil
[4] Univ Fed Parana, Dept Community Hlth, Curitiba, Parana - Brazil
[5] Univille Univ, Sch Dent, Joinville - Brazil
[6] Pontificia Univ Catolica Parana PUC PR, Dent Sch, Curitiba, Parana - Brazil
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ACTA ODONTOLOGICA SCANDINAVICA; v. 78, n. 6 JUL 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Objectives:The aim of this study is to evaluate the association between the single nucleotide polymorphism (SNP) rs4284505 within the gene that codifies microRNA17 (miRNA17) and dental fluorosis (DF) in a group of children. Methods:Children living in a city with fluoridation of public water supplies were included. DF was assessed in erupted permanent teeth by Dean's modified index. The miR-SNP rs4284505 was selected in miRNA17 and genotyping was carried out by real-time PCR. Genotype and allelic distributions between DF and control, and between DF phenotypes (mild, moderate and severe) and control were analysed. Results:Among a total of 527 children enrolled for the study, 383 were DF free and 144 presented DF. In the dominant model analysis (AA + AGvs.GG) the miR-SNP rs4284505 was associated with moderate DF, with carriers of the GG genotype having an increased risk of more than two times for DF (p = 0.031; Odds Ratio = 2.26, Confidence Interval 95%= 1.04-4.73). Allelic distribution showed borderline statistical significance for moderate DF with the carriers of G allele having an increased risk for DF (p = .050; Odds Ratio = 1.75, Confidence Interval 95%= 1.00-3.12). Conclusion:The miR-SNP rs4284505 in miRNA17 was associated with an increased risk of DF. (AU) | |
| Processo FAPESP: | 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial |
| Beneficiário: | Erika Calvano Kuchler |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 16/08149-1 - Avaliação do papel do estrógeno nos tecidos dentofaciais |
| Beneficiário: | Erika Calvano Kuchler |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |