Correlations among vitamin K intake, body fat, lipid profile and glucose homeostasis in adults and the elderly

Autor(es)

Elizabete A. dos Santos ^[1] ; Kelly V. Giudici ^[2] ; Natasha A. G. de França ^[3] ; Barbara S. Emo Peters ^[4] ; Regina Mara Fisberg ^[5] ; Lígia A. Martini ^[6]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil

^[2] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil

^[3] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil

^[4] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil

^[5] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil

^[6] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 64, n. 4, p. 436-444, 2020-04-06.

Resumo

ABSTRACT Objective Recent research has investigated the possible inverse relationship between vitamin K intake and body fat. In addition, an increasing number of studies are supporting a key role for this vitamin in improving lipid profile and insulin sensitivity and reducing the risk of type 2 diabetes mellitus, but little is known about what mechanisms would be involved. Thus, the objective of this study was to investigate the relationship between vitamin K intake (in the form of phylloquinone – PK), body fat, lipid profile and markers of glucose homeostasis in adults and the elderly. Subjects and methods A cross-sectional study with 298 participants (46% men) in the São Paulo Health Survey 2014-2015. Spearman correlations were performed to evaluate the associations between vitamin K intake and the biochemical and body composition measures. Results Among normal-weight male adults (n = 15), PK intake presented a positive correlation with the quantitative insulin sensitivity check index (QUICKI) (r = 0.525; p = 0.045). Among men with high fat mass index (FMI) (n = 101), PK intake had a negative correlation with homeostasis model assessment estimate for β-cell function (HOMA-β) (r = −0.227; p = 0.022). In women with high FMI (n = 122), PK intake had a negative correlation with HOMA-β (r = −0.199, p = 0.032) and insulin (r = −0.207, p = 0.026). No correlations were found between PK intake and lipid profile. Conclusions Our findings support a potential relationship among PK intake, body fat and markers of glucose homeostasis in adults and the elderly. (AU)

• Processo FAPESP: 15/07971-7 - Obesidade Osteosarcopênica: Interrelação com osteoporose, vitamina D, ingestão alimentar e risco de fraturas ósseas
• Beneficiário: Lígia Araújo Martini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/22113-9 - Indicadores bioquímicos do estado nutricional de micronutrientes e consumo alimentar habitual de residentes do Município de São Paulo - Estudo ISA 2013
• Beneficiário: Regina Mara Fisberg
• Modalidade de apoio: Auxílio à Pesquisa - Regular