HClO4-Al(2)O(3)as a Prominent Catalyst in the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones under Environmentally Friendly Solvent Conditions

Autor(es)

Zanin, Lucas L. ^[1] ; Porto, Andre L. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, Lab Quim Organ & Biocatalise, Ave Joao Dagnone, 1100, Ed Quim Ambiental, BR-13563120 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMISTRYSELECT; v. 5, n. 28, p. 8604-8608, JUL 31 2020.
• Citações Web of Science: 0

Resumo

An accessible, non-toxic, easy to handle and stock catalyst with high efficiency was developed in this study for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones. Al(2)O(3)was used as a support for HClO4, resulting in a heterogeneous and reusable catalyst for the Biginelli reaction. In the absence of the catalyst, the reaction provided a yield of 19%. However, in the presence of HClO4-Al(2)O(3)it was possible to synthesize 16 examples of DHPMs/thiones with improved yields (80-98%), in reaction periods of 1 to 3 hours. The catalyst also stood out for its stability against temperature and the reagents used. (AU)

• Processo FAPESP: 19/07654-2 - Reação de Biginelli (síntese e resolução quimioezimática) e biotransformação de esteroides por microrganismos
• Beneficiário: Andre Luiz Meleiro Porto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/20155-7 - Reações de aminólise e de resolução cinética por lipases e biodegradação de agroquímicos por microrganismos
• Beneficiário: Andre Luiz Meleiro Porto
• Modalidade de apoio: Auxílio à Pesquisa - Regular