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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

HClO4-Al(2)O(3)as a Prominent Catalyst in the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones under Environmentally Friendly Solvent Conditions

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Author(s):
Zanin, Lucas L. [1] ; Porto, Andre L. M. [1]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, Lab Quim Organ & Biocatalise, Ave Joao Dagnone, 1100, Ed Quim Ambiental, BR-13563120 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CHEMISTRYSELECT; v. 5, n. 28, p. 8604-8608, JUL 31 2020.
Web of Science Citations: 0
Abstract

An accessible, non-toxic, easy to handle and stock catalyst with high efficiency was developed in this study for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones. Al(2)O(3)was used as a support for HClO4, resulting in a heterogeneous and reusable catalyst for the Biginelli reaction. In the absence of the catalyst, the reaction provided a yield of 19%. However, in the presence of HClO4-Al(2)O(3)it was possible to synthesize 16 examples of DHPMs/thiones with improved yields (80-98%), in reaction periods of 1 to 3 hours. The catalyst also stood out for its stability against temperature and the reagents used. (AU)

FAPESP's process: 19/07654-2 - Biginelli reaction (synthesis and chemoenzymatic resolution) and biotransformation of steroids by microorganisms
Grantee:Andre Luiz Meleiro Porto
Support Opportunities: Regular Research Grants
FAPESP's process: 16/20155-7 - Biocatalytic reactions of aminolysis and kinetic resolution by lipases and biodegradation of agrochemicals by microorganisms
Grantee:Andre Luiz Meleiro Porto
Support Opportunities: Regular Research Grants