Scholarship 24/08164-7 - Doenças negligenciadas, Epoxidação - BV FAPESP
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Use of Metal-Organic Frameworks (MOFs) in the development of new drugs against neglected diseases

Grant number: 24/08164-7
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date until: December 01, 2024
End date until: November 30, 2026
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Dalmo Mandelli
Grantee:Ibrahim Abdurrahman Adam Mohammed
Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated research grant:23/01634-5 - Metal-Organic Frameworks (MOFs) as catalysts for sustainable oxidation of hydrocarbons derived from petroleum (methane and other alkanes) and natural (terpenes), AP.R

Abstract

Brazil's vast and diverse ecosystems are home to an extraordinary variety of plant species, making it a treasure trove of biodiversity. Among the countless compounds these plants produce, lignoids, neolignans, and terpenes stand out for their fascinating structures and promising applications in both traditional. Natural products have always been a source of medicines or prototypes for the design of drugs with improved properties. A recent collaboration between U. Rennes and UFABC has shown that the antiparasitic activities of natural products, extracted from Brazilian plants, can be enhanced by some chemical transformations. In this project, the extracted molecules will be modified using catalytic tools. Oxidation reactions will be carried out using hydrogen peroxide and heterogeneous catalysts, including Metal-Organic Frameworks (MOFs). Another key transformation involves metathesis reactions, which will initially be conducted in the presence of functionalized alkenes with shortened chains and homogeneous Ru-based catalysts (later heterogenized in MOFs), under mild conditions and using environmentally friendly solvents, such as dimethyl carbonate. The molecules synthesized from the oxidation and metathesis reactions with lignoids, neolignans, and terpenes will undergo evaluation for their biological activities against Chagas disease, Leishmaniasis, and Schistosomiasis. This evaluation will be conducted in partnership with research groups from the Adolfo Lutz Institute, University of Guarulhos, and UFABC. The utilization of Metal-Organic Frameworks (MOFs) prepared in the current FAPESP-sponsored project, along with the biological application of these new compounds, will provide significant contributions to the ongoing research.

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