MAPK7 variants related to prognosis and chemotherapy response in osteosarcoma

Autor(es)

Tesser-Gamba, Francine ^{[1, 2]} ; Paolillo, Alini Trujillo ^{[2, 3]} ; Paniago, Mario del Giudice ^[2] ; Petrilli, Antonio Sergio ^[2] ; Seixas Alves, Maria Teresa ^{[4, 2]} ; Garcia Filho, Reynaldo Jesus ^{[2, 5]} ; Caminada Toledo, Silvia Regina ^{[1, 2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Pediat Oncol Inst GRAACC, Dept Pediat, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Clin & Expt Oncol, Sao Paulo, SP - Brazil

^[4] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, SP - Brazil

^[5] Univ Fed Sao Paulo, Dept Orthoped Surg & Traumatol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANNALS OF DIAGNOSTIC PATHOLOGY; v. 46, JUN 2020.
• Citações Web of Science: 0

Resumo

Osteosarcoma (OS) is a class of cancer originating from the bone, affecting mainly children and young adults. Our previous study showed that MAPK7 gene overexpression was significantly associated with tumor progression, poor treatment response, and worse overall survival, suggesting that MAPK7 could play an important role in OS tumorigenesis. We have investigated if MAPK7 overexpression was a result of any genomic changes in OS tumor specimens. We identified five SNPs (Single Nucleotide Polymorphism) previously described in databases, dbSNP and COSMIC, and identified two single nucleotide substitution not yet described. We found, in prechemotherapy specimens, a significant association of MAPK7 rs2233072G allele variant with metastasis at diagnosis and relapse (0.0909 and 0.0455, respectively). In post-chemotherapy, rs1054206GG specimen's genotype was associated with osteoblastic histological type (P = 0.0249) and presented decreased MAPK7 gene expression when compared with pre-chemotherapy specimens of same patients (P = 0.0095). Interestingly, it was observed some SNPs genotype exchange after chemotherapy. Our data indicated that MAPK7 gene expression associated with genotype exchange after chemotherapy, and these SNPs associated with important clinical parameters might be a valuable indicator for predicting in OS. (AU)

• Processo FAPESP: 11/10459-5 - Caracterização molecular e funcional dos sarcomas ósseos e de partes moles da infância e da adolescência
• Beneficiário: Silvia Regina Caminada de Toledo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/10782-8 - Estudo funcional do gene MAPK7, proposto como marcador prognóstico em osteossarcoma.
• Beneficiário: Francine Tesser Gamba
• Modalidade de apoio: Bolsas no Brasil - Doutorado