MAPK7 variants related to prognosis and chemotherapy response in osteosarcoma

Author(s)

Tesser-Gamba, Francine ^{[1, 2]} ; Paolillo, Alini Trujillo ^{[2, 3]} ; Paniago, Mario del Giudice ^[2] ; Petrilli, Antonio Sergio ^[2] ; Seixas Alves, Maria Teresa ^{[4, 2]} ; Garcia Filho, Reynaldo Jesus ^{[2, 5]} ; Caminada Toledo, Silvia Regina ^{[1, 2, 3]}

Affiliation

^[1] Univ Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Pediat Oncol Inst GRAACC, Dept Pediat, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Clin & Expt Oncol, Sao Paulo, SP - Brazil

^[4] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, SP - Brazil

^[5] Univ Fed Sao Paulo, Dept Orthoped Surg & Traumatol, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: ANNALS OF DIAGNOSTIC PATHOLOGY; v. 46, JUN 2020.
• Web of Science Citations: 0

Abstract

Osteosarcoma (OS) is a class of cancer originating from the bone, affecting mainly children and young adults. Our previous study showed that MAPK7 gene overexpression was significantly associated with tumor progression, poor treatment response, and worse overall survival, suggesting that MAPK7 could play an important role in OS tumorigenesis. We have investigated if MAPK7 overexpression was a result of any genomic changes in OS tumor specimens. We identified five SNPs (Single Nucleotide Polymorphism) previously described in databases, dbSNP and COSMIC, and identified two single nucleotide substitution not yet described. We found, in prechemotherapy specimens, a significant association of MAPK7 rs2233072G allele variant with metastasis at diagnosis and relapse (0.0909 and 0.0455, respectively). In post-chemotherapy, rs1054206GG specimen's genotype was associated with osteoblastic histological type (P = 0.0249) and presented decreased MAPK7 gene expression when compared with pre-chemotherapy specimens of same patients (P = 0.0095). Interestingly, it was observed some SNPs genotype exchange after chemotherapy. Our data indicated that MAPK7 gene expression associated with genotype exchange after chemotherapy, and these SNPs associated with important clinical parameters might be a valuable indicator for predicting in OS. (AU)

• FAPESP's process: 11/10459-5 - Molecular e functional characterization of bone and soft tissue sarcomas of children and adolescents
• Grantee: Silvia Regina Caminada de Toledo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/10782-8 - Functional study of MAPK7 gene, proposed as a prognostic marker in osteosarcoma.
• Grantee: Francine Tesser Gamba
• Support Opportunities: Scholarships in Brazil - Doctorate