Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Autor(es):Mostrar menos -

Di Credico, Gioia ^[1] ; Polesel, Jerry ^[2] ; Dal Maso, Luigino ^[2] ; Pauli, Francesco ^[1] ; Torelli, Nicola ^[1] ; Luce, Daniele ^[3] ; Radoi, Loredana ^[4] ; Matsuo, Keitaro ^{[5, 6]} ; Serraino, Diego ^[2] ; Brennan, Paul ^[7] ; Holcatova, Ivana ^[8] ; Ahrens, Wolfgang ^{[9, 10]} ; Lagiou, Pagona ^[11] ; Canova, Cristina ^[12] ; Richiardi, Lorenzo ^[13] ; Healy, Claire M. ^[14] ; Kjaerheim, Kristina ^[15] ; Conway, David I. ^[16] ; Macfarlane, Gary J. ^[17] ; Thomson, Peter ^[18] ; Agudo, Antonio ^[19] ; Znaor, Ariana ^[7] ; Franceschi, Silvia ^[20] ; Herrero, Rolando ^[7] ; Toporcov, Tatiana N. ^[21] ; Moyses, Raquel A. ^[22] ; Muscat, Joshua ^[23] ; Negri, Eva ^[24] ; Vilensky, Marta ^[25] ; Fernandez, Leticia ^[26] ; Curado, Maria Paula ^[27] ; Menezes, Ana ^[28] ; Daudt, Alexander W. ^[29] ; Koifman, Rosalina ^[30] ; Wunsch-Filho, Victor ^[21] ; Olshan, Andrew F. ^[31] ; Zevallos, Jose P. ^[32] ; Sturgis, Erich M. ^[33] ; Li, Guojun ^[33] ; Levi, Fabio ^[34] ; Zhang, Zuo-Feng ^[35] ; Morgenstern, Hal ^{[36, 37, 38]} ; Smith, Elaine ^[39] ; Lazarus, Philip ^[40] ; La Vecchia, Carlo ^[41] ; Garavello, Werner ^[42] ; Chen, Chu ^[43] ; Schwartz, Stephen M. ^[43] ; Zheng, Tongzhang ^[44] ; Vaughan, Thomas L. ^[43] ; Kelsey, Karl ^[45] ; McClean, Michael ^[46] ; Benhamou, Simone ^[47] ; Hayes, Richard B. ^[48] ; Purdue, Mark P. ^[49] ; Gillison, Maura ^[50] ; Schantz, Stimson ^[51] ; Yu, Guo-Pei ^[52] ; Chuang, Shu-Chun ^[53] ; Boffetta, Paolo ^{[54, 55]} ; Hashibe, Mia ^{[56, 57]} ; Yuan-Chin, Amy Lee ^{[56, 57]} ; Edefonti, Valeria ^[41]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Trieste, Dept Econ Business Math & Stat, Trieste - Italy

^[2] IRCCS, Ctr Riferimento Oncol Aviano CRO, Canc Epidmiol Unit, Aviano - Italy

^[3] Univ Rennes, Irset Inst Rech Sante Environm & Travail, UMR S 1085, INSERM, EHESP, Pointe A Pitre, Guadeloupe - France

^[4] Ctr Res Epidemiol & Populat Hlth CESP, INSERM UMR 1018, Canc Epidemiol Genes & Environm Team, Villejuif - France

^[5] Aichi Canc Ctr, Div Canc Epidmiol & Prevent, Res Inst, Nagoya, Aichi - Japan

^[6] Nagoya Univ, Dept Canc Epidmiol, Grad Sch Med, Nagoya, Aichi - Japan

^[7] Int Agcy Res Canc, Lyon - France

^[8] Charles Univ Prague, Inst Hyg & Epidmiol, Fac Med 1, Prague - Czech Republic

^[9] Univ Bremen, Fac Math & Comp Sci, Bremen - Germany

^[10] Leibniz Inst Prevent Res & Epidmiol, BIPS, Bremen - Germany

^[11] Natl & Kapodistrian Univ Athens, Dept Hyg Epidmiol & Med Stat, Sch Med, Athens - Greece

^[12] Univ Padua, Padua - Italy

^[13] Univ Turin, Dept Med Sci, Turin - Italy

^[14] Trinity Coll Dublin, Sch Dent Sci, Dublin - Ireland

^[15] Canc Registry Norway, Oslo - Norway

^[16] Univ Glasgow, Sch Med Dent & Nursing, Glasgow, Lanark - Scotland

^[17] Univ Aberdeen, Sch Med Med Sci & Nutr, Aberdeen - Scotland

^[18] Univ Hong Kong, Hong Kong - Peoples R China

^[19] Bellvitge Biomed Res Inst IDIBELL, Unit Nutr & Canc, Catalan Inst Oncol ICO, Nutr & Canc Grp, Barcelona 08908 - Spain

^[20] IRCCS, Ctr Riferimento Oncol Aviano CRO, Sci Directorate, Aviano - Italy

^[21] Univ Sao Paulo, Sch Publ Hlth, Dept Epidmiol, Sao Paulo, SP - Brazil

^[22] Univ Sao Paulo, Sch Med, Head & Neck Surg, Sao Paulo, SP - Brazil

^[23] Penn State Coll Med, Hershey, PA - USA

^[24] Univ Milan, Dept Biomed & Clin Sci, Milan - Italy

^[25] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF - Argentina

^[26] Inst Oncol & Radiobiol, Havana - Cuba

^[27] CIPE ACCAMARGO, Epidmiol, Sao Paulo, SP - Brazil

^[28] Univ Fed Pelotas, Pelotas, RS - Brazil

^[29] Hosp Moinhos Vento, Porto Alegre, RS - Brazil

^[30] Fundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro - Brazil

^[31] Gillings Sch Global Publ Hlth, Dept Epidmiol, Chapel Hill, NC - USA

^[32] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Div Head & Neck Surg Oncol, St Louis, MO 63110 - USA

^[33] Baylor Coll Med, Dept Otolaryngol Head & Neck Surg, Houston, TX 77030 - USA

^[34] Univ Lausanne, Inst Univ Med Sociale & Prevent IUMSP, Unisante, Lausanne - Switzerland

^[35] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 - USA

^[36] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 - USA

^[37] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 - USA

^[38] Univ Michigan, Dept Urol, Med Sch, Ann Arbor, MI - USA

^[39] Univ Iowa, Coll Publ Hlth, Iowa City, IA - USA

^[40] Washington State Univ, Coll Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Spokane, WA - USA

^[41] Univ Milan, Branch Med Stat Biometry & Epidemiol GA Maccacaro, Dept Clin Sci & Community Hlth, Milan - Italy

^[42] Univ Milano Bicocca, Sch Med & Surg, Dept Otorhinolaryngol, Monza - Italy

^[43] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Div Publ Hlth Sci, Seattle, WA 98104 - USA

^[44] Brown Univ, Dept Epidmiol, Sch Publ Hlth, Providence, RI 02912 - USA

^[45] Brown Univ, Providence, RI 02912 - USA

^[46] Boston Univ, Sch Publ Hlth, Boston, MA 02215 - USA

^[47] Natl Inst Hlth & Med Res, INSERM U1018, Villejuif - France

^[48] NYU, Sch Med, Div Epidemiol, New York, NY - USA

^[49] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 - USA

^[50] Univ Texas MD Anderson Canc Ctr, Thorac Head & Neck Med Oncol, Houston, TX 77030 - USA

^[51] New York Eye & Ear Infirm, New York, NY - USA

^[52] Peking Univ, Med Informat Ctr, Beijing - Peoples R China

^[53] Natl Hlth Res Inst, Inst Populat Hlth Sci, Miaoli - Taiwan

^[54] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 - USA

^[55] Univ Bologna, Dept Med & Surg Sci, Bologna - Italy

^[56] Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT 84112 - USA

^[57] Huntsman Canc Inst, Salt Lake City, UT - USA

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF CANCER; v. 123, n. 9 AUG 2020.
• Citações Web of Science: 0

Resumo

Background Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk <= 10 drinks/day for <= 54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions Present results further encourage the reduction of alcohol intensity to mitigate HNC risk. (AU)

• Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
• Beneficiário: José Eluf Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 04/12054-9 - Busca de marcadores de agressividade em tumores de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Temático