Association between creatine kinase activity, oxidative stress and selenoproteins mRNA expression changes after Brazil nut consumption of patients using statins

Autor(es)

Watanabe, Ligia Moriguchi ^[1] ; de Lima, Livia Fernandes ^[1] ; Ferraz-Bannitz, Rafael ^[1] ; Takaara, Daniela ^[1] ; Romano, Beatriz Coimbra ^[2] ; Braga Costa, Telma Maria ^[2] ; Foss de Freitas, Maria Cristina ^[1] ; Bueno, Ana Carolina ^[3] ; Barbosa Junior, Fernando ^[4] ; Navarro, Anderson Marliere ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Internal Med, Sao Paulo - Brazil

^[2] Univ Ribeirao Preto UNAERP, Dept Nutr, Ribeirao Preto - Brazil

^[3] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Pediat, Sao Paulo - Brazil

^[4] Univ Sao Paulo FCFRP USP, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin & Toxicol Anal & Bromatol, Sao Paulo - Brazil

^[5] Univ Sao Paulo FMRP USP, Ribeirao Preto Med Sch, Dept Hlth Sci, Div Nutr & Metab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical Nutrition; v. 39, n. 10, p. 3175-3181, OCT 2020.
• Citações Web of Science: 0

Resumo

Background \& aims: Although the mechanisms by which statins promote muscle disorders remain unclear, supplementation with dietary antioxidants may mitigate statins' side effects. This study aimed to investigate whether the consumption of Brazil nuts modulates serum creatine kinase (CK) activity in patients regularly using statins. Methods: The study was performed in the Ribeirao Preto Medical School University Hospital. Thirty-two patients in regular use of statins were divided according to CK activity levels (G1: increased or G2: normal) and received one unit of Brazil nut daily for 3 months. Body composition, blood selenium (Se) concentrations, erythrocyte glutathione peroxidase (GPX) activity, oxidative stress parameters, and CK activity were evaluated before and after supplementation. Results: In both groups, supplementation with one Brazil nut daily for 3 months contributed to achieve decreased levels of CK activity in serum, with positive changes in plasma and erythrocyte Se concentrations (p < 0.0001), and increased levels of GPX activity. Among the parameters related to curbing of oxidative stress, we observed reduced levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in both groups after supplementation. We also found a moderately negative association between CK and GPX activity (r = -41; p < 0.02). Expression of selenoproteins GPXI, SELENOP, and SELENON after Brazil nut supplementation was unchanged. Conclusion: Brazil nut consumption enhanced the control of CK activity by improving oxidative stress biomarkers in patients using statins but did not modulate mRNA expression of selenoproteins. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. (AU)

• Processo FAPESP: 16/05677-7 - Efeito do consumo da castanha-do-brasil (Bertholetia excelsa H.B.K.) sobre selenocompostos no uso crônico de estatinas
• Beneficiário: Lígia Moriguchi Watanabe
• Modalidade de apoio: Bolsas no Brasil - Doutorado