| Texto completo | |
| Autor(es): |
Chiaramonte, Marco
[1]
;
Arizza, Vincenzo
[1]
;
La Rosa, Simona
[1]
;
Queiroz, Vinicius
[1, 2]
;
Mauro, Manuela
[1]
;
Vazzana, Mirella
[1]
;
Inguglia, Luigi
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Palermo, Dept STEBICEF, Via Archirafi 18, I-90123 Palermo - Italy
[2] Univ Sao Paulo, Inst Biosci, Dept Physiol, Rua Matao, Travessa 14, 101, BR-05508090 Sao Paulo, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ZOOLOGY; v. 142, OCT 2020. |
| Citações Web of Science: | 1 |
| Resumo | |
Echinoderms are a phylum of deuterostomic invertebrates that play a key role in maintaining the biodiversity of marine ecosystems. They represent a good study model for immunity because their coelomic fluid contains different types of cells involved in the inflammatory response: the coelomocytes. In the case of the sea urchin Paracentrotus lividus, the coelomocyte population is mainly represented by amoebocytes and uncoloured spherulocytes that implement a defence program through phagocytosis, encapsulation, cytotoxicity, and production of antimicrobial agents. The purpose of this study was to find evidence of a possible modulating effect of lipopolysaccharide LPS on the expression of the AIF-1 gene and therefore to determine whether or not there is a correlation between the P. lividus immune response and the expression of this gene when the homeostasis of the animals is disturbed by a bacterial infection which, in this case, was simulated with treatment with LPS. AIF-1 (Allograft Inflammatory Factor 1) is a 17 kDa calcium-binding protein that, in vertebrates, is involved in the activation of macrophages. Similarly, in Echinoids and in general in invertebrates, the expression of this gene increases considerably after a bacterial attack and this suggests that it plays a key role during the immune responses. (AU) | |
| Processo FAPESP: | 15/21460-5 - Função fisiológica, composição química e ontogenia dos esferulócitos em Echinoidea (Echinodermata). |
| Beneficiário: | Vinicius Queiroz Araújo |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 18/14497-8 - Função fisiológica e origem dos esferulócitos no ouriço-do-mar Paracentrotus lividus (Echinodermata: Echinoidea) |
| Beneficiário: | Vinicius Queiroz Araújo |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |