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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Allograft Inflammatory Factor AIF-1: early immune response in the Mediterranean sea urchin Paracentrotus lividus

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Author(s):
Chiaramonte, Marco [1] ; Arizza, Vincenzo [1] ; La Rosa, Simona [1] ; Queiroz, Vinicius [1, 2] ; Mauro, Manuela [1] ; Vazzana, Mirella [1] ; Inguglia, Luigi [1]
Total Authors: 7
Affiliation:
[1] Univ Palermo, Dept STEBICEF, Via Archirafi 18, I-90123 Palermo - Italy
[2] Univ Sao Paulo, Inst Biosci, Dept Physiol, Rua Matao, Travessa 14, 101, BR-05508090 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ZOOLOGY; v. 142, OCT 2020.
Web of Science Citations: 1
Abstract

Echinoderms are a phylum of deuterostomic invertebrates that play a key role in maintaining the biodiversity of marine ecosystems. They represent a good study model for immunity because their coelomic fluid contains different types of cells involved in the inflammatory response: the coelomocytes. In the case of the sea urchin Paracentrotus lividus, the coelomocyte population is mainly represented by amoebocytes and uncoloured spherulocytes that implement a defence program through phagocytosis, encapsulation, cytotoxicity, and production of antimicrobial agents. The purpose of this study was to find evidence of a possible modulating effect of lipopolysaccharide LPS on the expression of the AIF-1 gene and therefore to determine whether or not there is a correlation between the P. lividus immune response and the expression of this gene when the homeostasis of the animals is disturbed by a bacterial infection which, in this case, was simulated with treatment with LPS. AIF-1 (Allograft Inflammatory Factor 1) is a 17 kDa calcium-binding protein that, in vertebrates, is involved in the activation of macrophages. Similarly, in Echinoids and in general in invertebrates, the expression of this gene increases considerably after a bacterial attack and this suggests that it plays a key role during the immune responses. (AU)

FAPESP's process: 15/21460-5 - Physiological function, chemical composition and ontogeny of Echinoid spherulocytes (Echinodermata).
Grantee:Vinicius Queiroz Araújo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/14497-8 - Physiological function and origin of the spherulocytes in the sea urchin Paracentrotus lividus (Echinodermata: Echinoidea)
Grantee:Vinicius Queiroz Araújo
Support Opportunities: Scholarships abroad - Research Internship - Doctorate