| Texto completo | |
| Autor(es): |
Ribeiro, Aline Barbosa
[1]
;
Brognara, Fernanda
[1]
;
da Silva, Josiane Fernandes
[2]
;
Castania, Jaci Airton
[1]
;
Fernandes, Patricia Garani
[3]
;
Tostes, Rita C.
[2]
;
Salgado, Helio Cesar
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP - Brazil
[3] Univ Ctr North Paulista UNORP, Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 10, n. 1 NOV 6 2020. |
| Citações Web of Science: | 0 |
| Resumo | |
Baroreceptor and chemoreceptor reflexes modulate inflammatory responses. However, whether these reflexes attenuate periodontal diseases has been poorly examined. Thus, the present study determined the effects of electrical activation of the carotid sinus nerve (CSN) in rats with periodontitis. We hypothesized that activation of the baro and chemoreflexes attenuates alveolar bone loss and the associated inflammatory processes. Electrodes were implanted around the CSN, and bilateral ligation of the first mandibular molar was performed to, respectively, stimulate the CNS and induce periodontitis. The CSN was stimulated daily for 10 min, during nine days, in unanesthetized animals. On the eighth day, a catheter was inserted into the left femoral artery and, in the next day, the arterial pressure was recorded. Effectiveness of the CNS electrical stimulation was confirmed by hypotensive responses, which was followed by the collection of a blood sample, gingival tissue, and jaw. Long-term (9 days) electrical stimulation of the CSN attenuated bone loss and the histological damage around the first molar. In addition, the CSN stimulation also reduced the gingival and plasma pro-inflammatory cytokines induced by periodontitis. Thus, CSN stimulation has a protective effect on the development of periodontal disease mitigating alveolar bone loss and inflammatory processes. (AU) | |
| Processo FAPESP: | 18/10455-9 - Papel da ativação elétrica do nervo carotídeo, em ratos acordados, na atenuação das respostas inflamatórias-local e sistêmica-induzidas pela periodontite |
| Beneficiário: | Aline Barbosa Ribeiro |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 17/05163-6 - Papel do sistema nervoso autônomo parassimpático e simpático na modulação da sepse em ratos não anestesiados |
| Beneficiário: | Fernanda Brognara Penteado Dias |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |