Targeting flavonoids on modulation of metabolic syndrome

Autor(es)

Neri-Numa, Iramaia Angelica ^[1] ; Betim Cazarin, Cinthia Bau ^[2] ; Tasca Gois Ruiz, Ana Lucia ^[3] ; Paulino, Bruno Nicolau ^[4] ; Molina, Gustavo ^[5] ; Pastore, Glaucia Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Food Engn, Dept Food Sci, Lab Bioflavours & Bioact Cpds, UNICAMP, BR-13083862 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Dept Food & Nutr, Nutr & Metab Lab, UNICAMP, BR-13083862 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, BR-13083871 Campinas, SP - Brazil

^[4] Fed Univ Amazonas UFAM, Fac Pharmaceut Sci, BR-69080900 Manaus, Amazonas - Brazil

^[5] Fed Univ Jequitinhonha & Mucuri Valleys UFVJM, Inst Sci & Technol, Diamantina, MG - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Functional Foods; v. 73, OCT 2020.
• Citações Web of Science: 0

Resumo

Metabolic Syndrome (MetS) is a complex condition associated with cardiovascular risk factors and diabetes. The weight gain, especially the accumulation of central adipose tissue, may be the first leading cause of the MetS. It is important to highlight that the lifestyle choices considered as modifiable risk factors contribute to the increase in the incidence of the MetS in the population, such as sedentarism and food intake. There is evidence in the literature concerning the benefits associated with the Mediterranean diet, which is rich in polyphenols. Therefore, the flavonoids are a class of non-nutrient that can be extensively studied mainly to elucidate the mechanisms related to the action of these compounds in the modulation of the microbiota, DNA methylation and health improvement. Thus, this review summarized evidence linking flavonoid intake to obesity, insulin resistance, T2DM and cardiovascular diseases. (AU)

• Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
• Beneficiário: Glaucia Maria Pastore
• Modalidade de apoio: Auxílio à Pesquisa - Temático