Perspective: The Potential Effects of Naringenin in COVID-19

Autor(es)

Alberca, Ricardo Wesley ^{[1, 2]} ; Teixeira, Franciane Mouradian Emidio ^[3] ; Beserra, Danielle Rosa ^{[1, 2]} ; de Oliveira, Emily Araujo ^{[1, 2]} ; Andrade, Milena Mary de Souza ^{[1, 2]} ; Pietrobon, Anna Julia ^[3] ; Sato, Maria Notomi ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies, LIM 56, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 11, SEP 25 2020.
• Citações Web of Science: 0

Resumo

Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization in March 2020. Severe COVID-19 cases develop severe acute respiratory syndrome, which can result in multiple organ failure, sepsis, and death. The higher risk group includes the elderly and subjects with pre-existing chronic illnesses such as obesity, hypertension, and diabetes. To date, no specific treatment or vaccine is available for COVID-19. Among many compounds, naringenin (NAR) a flavonoid present in citrus fruits has been investigated for antiviral and anti-inflammatory properties like reducing viral replication and cytokine production. In this perspective, we summarize NAR potential anti-inflammatory role in COVID-19 associated risk factors and SARS-CoV-2 infection. (AU)

• Processo FAPESP: 19/02679-7 - Efeito da suplementação com antioxidante materna e paterna em processo inflamatório pulmonar da prole de camundongos
• Beneficiário: Ricardo Wesley Alberca Custódio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/18199-9 - Efeito da suplementação materna com o ácido retinoico durante a amamentação na resposta imunológica da prole de camundongos
• Beneficiário: Maria Notomi Sato
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/18230-6 - Avaliação da eficácia da vacina de DNA quimérica do Vírus Zika e da proteína de associação à membrana lisossomal em camundongos
• Beneficiário: Franciane Mouradian Emidio Teixeira
• Modalidade de apoio: Bolsas no Brasil - Doutorado