Future and Perspectives of the Zika Virus: Drug Repurposing as a Powerful Tool for Treatment Insights

Autor(es)

Rampini, Denise ^[1] ; Prieto, Diego Campos ^[1] ; Colzi, Ana Luisa ^[1] ; de Araujo, Renan Vinicius ^[1] ; Giarolla, Jeanine ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Av Prof Lineu Prestes 580, Cidade Univ, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: MINI-REVIEWS IN MEDICINAL CHEMISTRY; v. 20, n. 18, p. 1917-1928, 2020.
• Citações Web of Science: 0

Resumo

The Zika virus (ZIKV) infection is a major public health concern in Brazil and worldwide, being a rapidly spreading disease with possible severe complications for pregnant women and neonates. There is currently no preventative therapy or specific treatment available. Within this context, drug repositioning is a very promising approach for the discovery of new treatment compounds, since old drugs may become new ones. Therefore, this paper aims to perform a literature mini-review to identify promising compounds to combat this virus. The mechanism of action at the molecular level and the structure-activity relationship of prototypes are discussed. Among the candidates identified, we highlight sofosbuvir, chloroquine and suramin, which present a greater quantity of experimental data to draw on for our discussion. The current treatment is palliative; therefore, this study is of paramount importance in identifying drug candidates useful for combating ZIKV. (AU)

• Processo FAPESP: 17/21154-7 - Dendrímero de poliamidoamina (PAMAM) de primeira geração: planejamento e síntese de pró-fármaco potencialmente ativo em tuberculose
• Beneficiário: Renan Vinicius de Araujo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica