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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity

Texto completo
Autor(es):
Tavares, Caio A. M. [1] ; Bailey, Matthew A. [2] ; Girardi, Adriana C. C. [3]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Geriatr Cardiobgy Unit, Med Sch, Heart Inst InCor, Sao Paulo - Brazil
[2] Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh, Midlothian - Scotland
[3] Univ Sao Paulo, Heart Inst InCor, Lab Genet & Mol Cardiol, Med Sch, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN PHYSIOLOGY; v. 11, NOV 19 2020.
Citações Web of Science: 0
Resumo

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a public health crisis of major proportions. Advanced age, male gender, and the presence of comorbidities have emerged as risk factors for severe illness or death from COVID-19 in observation studies. Hypertension is one of the most common comorbidities in patients with COVID-19. Indeed, hypertension has been shown to be associated with increased risk for mortality, acute respiratory distress syndrome, need for intensive care unit admission, and disease progression in COVID-19 patients. However, up to the present time, the precise mechanisms of how hypertension may lead to the more severe manifestations of disease in patients with COVID-19 remains unknown. This review aims to present the biological plausibility linking hypertension and higher risk for COVID-19 severity. Emphasis is given to the role of the renin-angiotensin system and its inhibitors, given the crucial role that this system plays in both viral transmissibility and the pathophysiology of arterial hypertension. We also describe the importance of the immune system, which is dysregulated in hypertension and SARS-CoV-2 infection, and the potential involvement of the multifunctional enzyme dipeptidyl peptidase 4 (DPP4), that, in addition to the angiotensin-converting enzyme 2 (ACE2), may contribute to the SARS-CoV-2 entrance into target cells. The role of hemodynamic changes in hypertension that might aggravate myocardial injury in the setting of COVID-19, including endothelial dysfunction, arterial stiffness, and left ventricle hypertrophy, are also discussed. (AU)

Processo FAPESP: 20/05338-3 - Modulação da ECA2 na hipertensão experimental e em resposta ao tratamento com IECA e BRA: potenciais implicações na gravidade e alvos terapêuticos da COVID-19
Beneficiário:Adriana Castello Costa Girardi
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/22140-7 - Bases moleculares da função e da disfunção tubular renal
Beneficiário:Adriana Castello Costa Girardi
Linha de fomento: Auxílio à Pesquisa - Temático