Prevalence of p16 expression in oropharyngeal squamous cell carcinoma in southern Brazil

Autor(es)

Girardi, Fabio Muradas ^[1] ; Wagner, Vivian P. ^[2] ; Martins, Manoela Domingues ^{[2, 3, 4]} ; Abentroth, Aliende Lengler ^[1] ; Hauth, Luiz Alberto ^[1]

Afiliação do(s) autor(es)

^[1] Ana Nery Hosp, Integrated Oncol Ctr, Santa Cruz Do Sul, RS - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil

^[3] Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, RS - Brazil

^[4] Porto Alegre Clin Hosp HCPA UFRGS, Dept Oral Med, Porto Alegre, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 130, n. 6, p. 681-691, DEC 2020.
• Citações Web of Science: 0

Resumo

Objective. Our aim was to evaluate the prevalence of human papillomavirus (HPV)-positive tumors in a cohort of patients with oropharyngeal squamous cell carcinoma (OPSCC) at a single center in southern Brazil and determine the short-term prognostic factors in this sample. Study Design. Ninety-one consecutive patients with newly diagnosed primary OPSCC between January 2017 and December 2019 were retrospectively included. Demographic, clinical, pathologic, and survival data were collected. HPV status was determined by using p16 immunohistochemistry. Results. The overall prevalence of HPV-positive (HPV+) OPSCC was 20.9%. Patients with HPV+ tumors presented a nodal metastasis as the first clinical sign (P =.02); reported less alcohol (P <.001) and tobacco use (P <.001); exhibited lower tumor stages (P <.001) and higher microscopic grades (P =.01); and had higher chances of having resectable tumors (P =.008). p16-negative status (P =.01); unresectable/inoperable tumors (P <.001); presence of nodal metastasis (P =.005); and higher American Joint Committee on Cancer (AJCC) stage (P =.002) were significantly associated with worse disease-specific survival. Conclusions. The prevalence of HPV+ OPSCC in southern Brazil is relatively low, and p16-positive status was associated with Better prognosis. Higher AJCC stage, nodal metastasis, and unresectability/inoperability were associated with the highest hazard ratios for death resulting from OPSCC. (AU)

• Processo FAPESP: 16/21785-4 - Relação da via de sinalização BDNF/TRKB com a agressividade e perfil de células tronco tumorais de neoplasias malignas de glândula salivar
• Beneficiário: Vivian Petersen Wagner
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado